中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
6期
732-735
,共4页
邱海燕%狄亚珍%蔡挺%李蕴言%吴菱%覃世榕%冯意红%林亚红
邱海燕%狄亞珍%蔡挺%李蘊言%吳蔆%覃世榕%馮意紅%林亞紅
구해연%적아진%채정%리온언%오릉%담세용%풍의홍%림아홍
黏膜皮肤淋巴结综合征/代谢%抗原,CD95/血液%儿童
黏膜皮膚淋巴結綜閤徵/代謝%抗原,CD95/血液%兒童
점막피부림파결종합정/대사%항원,CD95/혈액%인동
Mucocutaneous lymph node syndrome/metabolism%Antigens,CD95/blood%Child
目的 观察急性期川崎病(KD)、不完全川崎病(IKD)患儿和正常对照组3组之间的血清可溶性Fas(sFas)的表达水平,探讨sFas与IKD患儿的关联作用.方法 选取本院住院治疗的急性期KD和急性期IKD患儿各32例,正常对照组20例,各组采用双抗夹心酶联免疫吸附试验(ELISA)检测血清sFas的含量,并行超声心动图检查,比较其sFas与IKD患儿的关联作用.结果 (1)急性期KD组和急性期IKD组血清sFas水平高于对照组[(0.54±0.20) ng/L、(0.55±0.16) ng/Lvs (0.24±0.04) ng/L,p＜0.05];急性期KD组和急性期IKD组sFas水平高于对照组(F=29.276,P＜0.05).(2)急性期IKD组超声心动图异常组与超声心动图正常组血清sFas水平比较差异有统计学意义[(0.65±0.19)ng/Lvs(0.49±0.10) ng/L,t=3.139,P＜0.05].KD组、IKD组sFas与PT-D、D-D、CRP、WBC均呈正相关(r=0.353～0.693,P＜0.05),与PLT无关(P＞0.05).结论 急性期IKD患儿的外周血清sFas水平呈高表达,其与急性期IKD患儿的心血管损害关系密切相关.
目的 觀察急性期川崎病(KD)、不完全川崎病(IKD)患兒和正常對照組3組之間的血清可溶性Fas(sFas)的錶達水平,探討sFas與IKD患兒的關聯作用.方法 選取本院住院治療的急性期KD和急性期IKD患兒各32例,正常對照組20例,各組採用雙抗夾心酶聯免疫吸附試驗(ELISA)檢測血清sFas的含量,併行超聲心動圖檢查,比較其sFas與IKD患兒的關聯作用.結果 (1)急性期KD組和急性期IKD組血清sFas水平高于對照組[(0.54±0.20) ng/L、(0.55±0.16) ng/Lvs (0.24±0.04) ng/L,p＜0.05];急性期KD組和急性期IKD組sFas水平高于對照組(F=29.276,P＜0.05).(2)急性期IKD組超聲心動圖異常組與超聲心動圖正常組血清sFas水平比較差異有統計學意義[(0.65±0.19)ng/Lvs(0.49±0.10) ng/L,t=3.139,P＜0.05].KD組、IKD組sFas與PT-D、D-D、CRP、WBC均呈正相關(r=0.353～0.693,P＜0.05),與PLT無關(P＞0.05).結論 急性期IKD患兒的外週血清sFas水平呈高錶達,其與急性期IKD患兒的心血管損害關繫密切相關.
목적 관찰급성기천기병(KD)、불완전천기병(IKD)환인화정상대조조3조지간적혈청가용성Fas(sFas)적표체수평,탐토sFas여IKD환인적관련작용.방법 선취본원주원치료적급성기KD화급성기IKD환인각32례,정상대조조20례,각조채용쌍항협심매련면역흡부시험(ELISA)검측혈청sFas적함량,병행초성심동도검사,비교기sFas여IKD환인적관련작용.결과 (1)급성기KD조화급성기IKD조혈청sFas수평고우대조조[(0.54±0.20) ng/L、(0.55±0.16) ng/Lvs (0.24±0.04) ng/L,p＜0.05];급성기KD조화급성기IKD조sFas수평고우대조조(F=29.276,P＜0.05).(2)급성기IKD조초성심동도이상조여초성심동도정상조혈청sFas수평비교차이유통계학의의[(0.65±0.19)ng/Lvs(0.49±0.10) ng/L,t=3.139,P＜0.05].KD조、IKD조sFas여PT-D、D-D、CRP、WBC균정정상관(r=0.353～0.693,P＜0.05),여PLT무관(P＞0.05).결론 급성기IKD환인적외주혈청sFas수평정고표체,기여급성기IKD환인적심혈관손해관계밀절상관.
Objective To compare the levels of sFas in the sera among Kawasaki disease (KD),incomplete Kawasaki disease (IKD),and normal control groups,and to analyze the relationship of sFas with IKD children.Methods A total of 32 cases of acute KD and acute IKD children,and 20 cases of the control children were selected,respectively.The levels of serum sFas among three groups were measured using ELISA kits.Each child among the three groups was examined by echocardiography.Results (1)The levels of serum sFas among the three groups were[ (0.54±0.20)ng/L in KD,(0.55±0.16)ng/L in IKD,and (0.24 ± 0.04) ng/L] in control group,respectively.The overall means of sFas in the KD and IKD groups were higher than the control group,and the differences were statistically significant( F=29.276,P＜0.05 ).(2)The levels of serum sFas among echocardiography abnormal and normal groups were[ (0.65±0.19) ng/L and (0.49±0.10)ng/L],respectively; and the difference between two groups were statistically significant ( t=3.139,P ＜ 0.05 ).Conclusions The expression levels of sFas in the peripheral serum of IKD children were increased,and there was a close association of overexpression of sFas with the cardiovascular damage in IKD children.
