肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
4期
250-251
,共2页
胰腺肿瘤%p21活化激酶类
胰腺腫瘤%p21活化激酶類
이선종류%p21활화격매류
Pancreatic neoplasms%p21-activated kinase
目的 探讨p21活化激酶1(PAK1)蛋白在胰腺癌中的表达及其意义.方法 选取胰腺癌组织标本33例作为研究组,胰腺癌周围正常组织标本33例作为对照组,应用免疫组织化学技术检测组织中PAK1蛋白的表达情况.结果 研究组中PAK1蛋白的阳性表达率明显高于对照组[69.7％(23/33)比27.3％(9/33),x2=11.89,P=0.001];且Ⅲ+Ⅳ期胰腺癌组织中PAK1阳性表达率高于Ⅰ+Ⅱ期[93.3％(14/15)比50.0％(9/18),x2=5.367,P=0.021].结论 PAK1蛋白可能与胰腺癌发生、发展有关.
目的 探討p21活化激酶1(PAK1)蛋白在胰腺癌中的錶達及其意義.方法 選取胰腺癌組織標本33例作為研究組,胰腺癌週圍正常組織標本33例作為對照組,應用免疫組織化學技術檢測組織中PAK1蛋白的錶達情況.結果 研究組中PAK1蛋白的暘性錶達率明顯高于對照組[69.7％(23/33)比27.3％(9/33),x2=11.89,P=0.001];且Ⅲ+Ⅳ期胰腺癌組織中PAK1暘性錶達率高于Ⅰ+Ⅱ期[93.3％(14/15)比50.0％(9/18),x2=5.367,P=0.021].結論 PAK1蛋白可能與胰腺癌髮生、髮展有關.
목적 탐토p21활화격매1(PAK1)단백재이선암중적표체급기의의.방법 선취이선암조직표본33례작위연구조,이선암주위정상조직표본33례작위대조조,응용면역조직화학기술검측조직중PAK1단백적표체정황.결과 연구조중PAK1단백적양성표체솔명현고우대조조[69.7％(23/33)비27.3％(9/33),x2=11.89,P=0.001];차Ⅲ+Ⅳ기이선암조직중PAK1양성표체솔고우Ⅰ+Ⅱ기[93.3％(14/15)비50.0％(9/18),x2=5.367,P=0.021].결론 PAK1단백가능여이선암발생、발전유관.
Objective To investigate the role of PAK1 in the development of pancreatic cancer.Methods 33 cases of pancreatic cancer in Renmin Hospital of XianTao were selected in this study. 33cases of pericancerous normal tissues were collected as control group.Immunohistochemical staining were performed to detect the expression of PAK1 in 33 cases of pancreatic cancer and pericancerous normal specimens.Results By Immunohistochemical staining PAK1 were mainly expressed in the cytoplasm. The positive rate of PAK1 expression in pancreatic cancer were 69.7 ％(23 / 33),which was significantly higher than that of control group[27.3 ％(9 / 33),x2=11.89,P =0.001].In addition,overexpression of PAK1 was more frequently in Ⅲ+Ⅳ stage pancreatic cancer tissue[93.3 ％(14/15)],compared with Ⅰ + Ⅱ stage [50.0 ％( 9 / 18 ),x2=5.367,P=0.021]. Conclusion The PAK1 protein may be associated with the occurrence and development of pancreatic cancer.
