CAJ | 학술논문

目的研究多发性骨髓瘤(multiple myeloma,MM)患者1q21扩增、13q14缺失、TP53基因缺失及IgH易位的发生率及预后意义.方法应用CD138单克隆抗体磁珠分选结合间期荧光原位杂交技术检测43例MM患者上述各种核型异常.结果 43例患者中28例(65.1%)出现了1q21的扩增,30例(69.7%)出现了13q14的缺失,8例(18.6%)出现了TP53基因的缺失,29例(67.4%)出现了IgH易位.1q21扩增、13q14缺失和TP53基因缺失与MM高死亡率有密切相关性.结论 1q21扩增、13q14缺失、TP53基因缺失及IgH易位是MM常见的核型异常,1q21扩增、13q14缺失和TP53基因缺失是MM的预后不良因子.
목적 연구다발성골수류(multiple myeloma,MM)환자1q21확증、13q14결실、TP53기인결실급IgH역위적발생솔급예후의의.방법 응용CD138단극륭항체자주분선결합간기형광원위잡교기술검측43례MM환자상술각충핵형이상.결과 43례환자중28례(65.1%)출현료1q21적확증,30례(69.7%)출현료13q14적결실,8례(18.6%)출현료TP53기인적결실,29례(67.4%)출현료IgH역위.1q21확증、13q14결실화TP53기인결실여MM고사망솔유밀절상관성.결론 1q21확증、13q14결실、TP53기인결실급IgH역위시MM상견적핵형이상,1q21확증、13q14결실화TP53기인결실시MM적예후불량인자.
Objective To investigate the incidence and prognosis of 1q21 amplification, 13q14 deletion, TP53 gene deletion and IgH translocation in patients with multiple myeloma (MM). Methods Interphase fluorescence in situ hybridization (I-FISH) with four different specific probes for the regions containing 1q21, 13q14.3 (D13S319), 14q32 and TP53 gene were performed in 43 MM patients. Results Among the 43 MM patients, 1q21 amplification was observed in 28 (65. 1%) cases, 13q14 deletion in 30 (69.7%) cases, TP53 gene deletion in 8 (18.6%) cases, and IgH translocation in 29 (67. 4%) cases. The mortality of MM patients with 1q21 amplification, 13q14 deletion or TP53 gene deletion was higher than those without them. Conclusion There is high frequencyof 1q21 amplification, 13q14 deletion, TP53 gene deletion and IgH translocation in multiple myeloma, and 1q21 amplification, 13q14 deletion and TP53 gene deletion are poor prognosis factors for MM patients.