肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2008年
10期
685-687
,共3页
程祝忠%许国辉%黄娟%杨宇洁%曹英%何韧%席晓秋
程祝忠%許國輝%黃娟%楊宇潔%曹英%何韌%席曉鞦
정축충%허국휘%황연%양우길%조영%하인%석효추
胰腺肿瘤%体层摄影术,X线计算机%灌注
胰腺腫瘤%體層攝影術,X線計算機%灌註
이선종류%체층섭영술,X선계산궤%관주
Pancreatic neoplasm%Tomography,X-ray computed%Perfusion
目的 应用MSCT灌注成像技术测量和评价正常胰腺和胰腺癌的血流动力学表现,探讨其在胰腺癌诊断中的临床应用价值.方法 对44例无胰腺疾病患者(正常胰腺患者)、18例胰腺癌患者行MSCT胰腺灌注检查,采用Siemens Bodyperfusion软件测量正常胰腺患者及胰腺癌患者的CT灌注参数值,包括血流量(BF)、血容量(BV)、灌注起始时间(TTS)、峰值到达时间(TTP)、渗透性(permeability)、patlak血流容积(pBV)的平均值,并进行统计学分析.结果 正常胰腺组的BF、BV、TTS、TTP、permeability和pBV分别为:(90.60±29.25)ml·100 ml-1·min-1、(190.35±43.8)ml/L、(205.3±16022)s、(1403.5±334.0)s、(99.47±49.9)05 ml·100ml-1·min-1和(157.8±52.5)ml/L,胰腺癌组的BF、BV、TTS、TTP、permeability和pBV分别为:(22.9±10.63)ml·100 ml-1·min-1、(52.38±18.08)ml/L、(194.3±76.0)s、(1549.5±308.5)s、(115.25±33.55)0.5·100 ml-1·min-1和(83.16±41.45)ml/L.胰腺癌组BF、Bv、pBV明显低于正常组,渗透性高于正常胰腺组,其差异有统计学意义(P<0.01);而两组的TTS和TTP值比较差异无统计学意义(P>0.05).结论 正常胰腺和胰腺癌的CT灌注参数值存在差异,MSCT灌注成像对胰腺癌的诊断有一定的临床价值.
目的 應用MSCT灌註成像技術測量和評價正常胰腺和胰腺癌的血流動力學錶現,探討其在胰腺癌診斷中的臨床應用價值.方法 對44例無胰腺疾病患者(正常胰腺患者)、18例胰腺癌患者行MSCT胰腺灌註檢查,採用Siemens Bodyperfusion軟件測量正常胰腺患者及胰腺癌患者的CT灌註參數值,包括血流量(BF)、血容量(BV)、灌註起始時間(TTS)、峰值到達時間(TTP)、滲透性(permeability)、patlak血流容積(pBV)的平均值,併進行統計學分析.結果 正常胰腺組的BF、BV、TTS、TTP、permeability和pBV分彆為:(90.60±29.25)ml·100 ml-1·min-1、(190.35±43.8)ml/L、(205.3±16022)s、(1403.5±334.0)s、(99.47±49.9)05 ml·100ml-1·min-1和(157.8±52.5)ml/L,胰腺癌組的BF、BV、TTS、TTP、permeability和pBV分彆為:(22.9±10.63)ml·100 ml-1·min-1、(52.38±18.08)ml/L、(194.3±76.0)s、(1549.5±308.5)s、(115.25±33.55)0.5·100 ml-1·min-1和(83.16±41.45)ml/L.胰腺癌組BF、Bv、pBV明顯低于正常組,滲透性高于正常胰腺組,其差異有統計學意義(P<0.01);而兩組的TTS和TTP值比較差異無統計學意義(P>0.05).結論 正常胰腺和胰腺癌的CT灌註參數值存在差異,MSCT灌註成像對胰腺癌的診斷有一定的臨床價值.
목적 응용MSCT관주성상기술측량화평개정상이선화이선암적혈류동역학표현,탐토기재이선암진단중적림상응용개치.방법 대44례무이선질병환자(정상이선환자)、18례이선암환자행MSCT이선관주검사,채용Siemens Bodyperfusion연건측량정상이선환자급이선암환자적CT관주삼수치,포괄혈류량(BF)、혈용량(BV)、관주기시시간(TTS)、봉치도체시간(TTP)、삼투성(permeability)、patlak혈류용적(pBV)적평균치,병진행통계학분석.결과 정상이선조적BF、BV、TTS、TTP、permeability화pBV분별위:(90.60±29.25)ml·100 ml-1·min-1、(190.35±43.8)ml/L、(205.3±16022)s、(1403.5±334.0)s、(99.47±49.9)05 ml·100ml-1·min-1화(157.8±52.5)ml/L,이선암조적BF、BV、TTS、TTP、permeability화pBV분별위:(22.9±10.63)ml·100 ml-1·min-1、(52.38±18.08)ml/L、(194.3±76.0)s、(1549.5±308.5)s、(115.25±33.55)0.5·100 ml-1·min-1화(83.16±41.45)ml/L.이선암조BF、Bv、pBV명현저우정상조,삼투성고우정상이선조,기차이유통계학의의(P<0.01);이량조적TTS화TTP치비교차이무통계학의의(P>0.05).결론 정상이선화이선암적CT관주삼수치존재차이,MSCT관주성상대이선암적진단유일정적림상개치.
Objective To assess the diagnostic value of multiple-slice spiral CT (MSCT) perfusion imaging technique in pancreatic cancer by measuring and comparing the dynamical characteristics of blood flow between normal pancreas and pancreatic cancer. Methods The CT perfusion imaging were obtained using Siemens Somatoma MSCT scanner in 44 patients with normal pancreas tissue and 18 patients with pancreatic cancer. The mean blood flow (BF),blood volume (BV), time to start (Trs), time to peak (TIP), permeability and patlak blood volume (pBV) were measured and statistically analyzed by using Siemens Body peHusion software package. Results The mean BF, BV, Trs, TIP, permeability and pBV of normal pancreas were: (90.60±29.25) ml·100 ml-1·min-1, (190.35±43.8) ml/L, (205.3±160.2) s, (1403.5±334.0)s, (99.47±49.9) 0.5 ml·100 ml-1·min-1, (157.8±52.5) ml/L, respectively. The mean BF, BV, TTS, TrP, per-meability and pBV of pancreatic cancer were (22.9±10. 63) ml·100 ml-1·min-1, (52.38±18.08) ml/L, (194.3±76.0) s, (1549.5± 308.5)s, (115.25±33.55) 0.5 ml·100 ml-1·min-1, (83.16±41.45) ml/L respectively. The mean BF, BV, pBV and permeability between normal pancreas and pancreatic carcinoma were statistically significant (P<0.01). However the mean TTS and TIP between normal pancreas and pancreatic carcinoma were not statistically significant (P>0.05). Conclusion There are significant differences between perfusion values of pancreatic carcinoma and normal pancreatic tissue, and MSCT perfusion imaging is helpful in diagnosing pancreatic carcinoma.
