中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2008年
5期
313-315
,共3页
刘永宏%杨旭红%廖伟%刘凌%鄢波%林旭%杨天华%徐鸿儒%陈华富%周东
劉永宏%楊旭紅%廖偉%劉凌%鄢波%林旭%楊天華%徐鴻儒%陳華富%週東
류영굉%양욱홍%료위%류릉%언파%림욱%양천화%서홍유%진화부%주동
癫(癎),部分性%发作%脑电描记术%磁共振成像
癲(癎),部分性%髮作%腦電描記術%磁共振成像
전(간),부분성%발작%뇌전묘기술%자공진성상
Epilepsies,partial%Seizures%Electroencephalography%Magnetic resonance imaging
目的 探讨部分性癫(癎)(癎)性放电相关血氧水平依赖(BOLD)信号的分布规律,为进一步研究该病的发病机制、脑功能变化奠定基础.方法 采用同步脑电图一功能磁共振成像(EEG-fMRI)技术,对2例部分性癫(癎)患者进行发作问期(癎)性放电相关BOLD变化的研究,探讨该病发作间期(癎)性放电相关BOLD信号与临床脑电图定位脑区的相互关系.结果 2例患者的临床脑电图定位脑区均出现了最大激活信号,其中1例在该区域有2处显著激活;在该区对侧相应脑区也有较弱的激活信号出现.结论 部分性癫(癎)(癎)性放电相关BOLD反应以(癎)性放电脑区为主,但其对侧同源脑区也有较弱的激活信号,fMRI激活信号与脑电活动之间有着很好的对应关系.
目的 探討部分性癲(癎)(癎)性放電相關血氧水平依賴(BOLD)信號的分佈規律,為進一步研究該病的髮病機製、腦功能變化奠定基礎.方法 採用同步腦電圖一功能磁共振成像(EEG-fMRI)技術,對2例部分性癲(癎)患者進行髮作問期(癎)性放電相關BOLD變化的研究,探討該病髮作間期(癎)性放電相關BOLD信號與臨床腦電圖定位腦區的相互關繫.結果 2例患者的臨床腦電圖定位腦區均齣現瞭最大激活信號,其中1例在該區域有2處顯著激活;在該區對側相應腦區也有較弱的激活信號齣現.結論 部分性癲(癎)(癎)性放電相關BOLD反應以(癎)性放電腦區為主,但其對側同源腦區也有較弱的激活信號,fMRI激活信號與腦電活動之間有著很好的對應關繫.
목적 탐토부분성전(간)(간)성방전상관혈양수평의뢰(BOLD)신호적분포규률,위진일보연구해병적발병궤제、뇌공능변화전정기출.방법 채용동보뇌전도일공능자공진성상(EEG-fMRI)기술,대2례부분성전(간)환자진행발작문기(간)성방전상관BOLD변화적연구,탐토해병발작간기(간)성방전상관BOLD신호여림상뇌전도정위뇌구적상호관계.결과 2례환자적림상뇌전도정위뇌구균출현료최대격활신호,기중1례재해구역유2처현저격활;재해구대측상응뇌구야유교약적격활신호출현.결론 부분성전(간)(간)성방전상관BOLD반응이(간)성방전뇌구위주,단기대측동원뇌구야유교약적격활신호,fMRI격활신호여뇌전활동지간유착흔호적대응관계.
Objective To investigate the map and pattern of blood oxygen level dependent(BOLD)signal changes correlated to interictal epileptiform discharges(IEDs)with EEG-fMRI in patients with partial epilepsy and then to explore the pathophysiological mechanisms of epileptic discharges and their effect on brain function in partial epilepsy.Methods Through the method of EEG-fMRI,2 patients with parial epilepsy were studied.The relationship between the regions of BOLD signal changes linked to IEDs and the electroelinical localization of epileptogenic zone in patients with partial epilepsy were investigated.Results The epileptogenic areas localized by electroclinical findings in the 2 patients all showed maximal activation and 2 sites of significant activation were found in 1 of the 2 patients;Weak activation were also manifested in the opposite side corresponding to lesions.Conclusions IED-linked BOLD response in patients with partial epilepsy is mainly in epileptogenic zones and weak activation can also be seen in the corresponding contralateral areas of epileptogenic zoiles.Activation areas ale well concordant with epileptogenie areas localized by electroclinical findings.
