CAJ | 학술논문

比较各方案的疗效和能否改善血管内皮功能.患者分为接受门冬胰岛素30、门冬胰岛素+甘精胰岛素、普通短效人胰岛素+中效人胰岛素或门冬胰岛素持续皮下输入4组.行指尖、静脉和动态血糖监测,统计胰岛素用量、费用,血管彩超评测血管内皮功能.达标后各方案血糖控制无显著差异；血管内皮功能无显著改善.各方案短期疗效相当;短期强化治疗未显著改善血管内皮功能.
비교각방안적료효화능부개선혈관내피공능.환자분위접수문동이도소30、문동이도소+감정이도소、보통단효인이도소+중효인이도소혹문동이도소지속피하수입4조.행지첨、정맥화동태혈당감측,통계이도소용량、비용,혈관채초평측혈관내피공능.체표후각방안혈당공제무현저차이；혈관내피공능무현저개선.각방안단기료효상당;단기강화치료미현저개선혈관내피공능.
To compare the effects of four different intensive insulin therapies on blood glucose control and vascular endothelial function in newly-diagnosed type 2 diabetes.Patients were randomly divided to accept pre-meal insulin aspart 30 or pre-meal insulin aspart and glargine at bedtime or pre-meal Novolin-R and NPH at bedtime or continuous subcutaneous insulin aspart infusion.Capillary blood glucose determination and continuous glucose monitoring system were carried out,therapeutic time and total insulin dosage were recorded.Ultrasound was used to evaluate the vascular endothelial function.Glucose level,incidence of low glucose,potency ratio of the four groups were similar( P＞0.05 ) ; FMD and NMD were not significantly improved ( P =0.718,P =0.065 ).The short-term efficacy and safety of the four groups are similar.The short-term intensive insulin therapy has no obvious effect on vascular endothelial function.