CAJ | 학술논문

目的探讨rs501120、rs17465637基因多态性在中国汉族人群中的分布及其与冠心病(CHD)的关系.方法采用病例对照研究,选取未治疗过的CHD患者775例及性别年龄匹配的对照组775例.采用TaqMan-MGB探针检测rs501120、rs17465637两个单核苷酸位点的多态性(SNPs).结果 rs501120、rs17465637的基因型频率在CHD组和对照组之间差异均无统计学意义(P＞0.05).进一步分层研究发现:在年龄＜60岁或糖尿病人群中,rs501120位点的CC纯合子在CHD发病中有显著保护作用(年龄＜60岁人群:OR 0.4,95%CI 0.2-0.9,P＜0.05;糖尿病人群:0R 0.3,95%CI 0.1-0.7,P＜0.05).结论在年龄＜60岁或糖尿病人群中,rs501120基因多态性与CHD的发病密切相关.
목적 탐토rs501120、rs17465637기인다태성재중국한족인군중적분포급기여관심병(CHD)적관계.방법 채용병례대조연구,선취미치료과적CHD환자775례급성별년령필배적대조조775례.채용TaqMan-MGB탐침검측rs501120、rs17465637량개단핵감산위점적다태성(SNPs).결과 rs501120、rs17465637적기인형빈솔재CHD조화대조조지간차이균무통계학의의(P＞0.05).진일보분층연구발현:재년령＜60세혹당뇨병인군중,rs501120위점적CC순합자재CHD발병중유현저보호작용(년령＜60세인군:OR 0.4,95%CI 0.2-0.9,P＜0.05;당뇨병인군:0R 0.3,95%CI 0.1-0.7,P＜0.05).결론 재년령＜60세혹당뇨병인군중,rs501120기인다태성여CHD적발병밀절상관.
Objective To investigate the rs501120 and rs17465637 gene polymorphisms,and their relationship with the risk of coronary heart disease(CHD)in Chinese Han population.Methods 775 CHD without treatment and 775 age and gender matched controls were selected for this study,the genotypes of two single nucleotide polymorphisms(SNP)rs501120 and rs17465637 were tested with TaqMan-MGB probes.Results There was no significant difference in the frequency of genotypes of the 2 SNPs between CHD group and control group(P ＞0.05).Stratified analysis showed that SNP rs501120 had significant protection with CHD in people younger than 60 years old(OR 0.4,95% CI 0.2-0.9,P ＜ 0.05)or people with diabetes(OR0.3,95%CI0.1-0.7,P ＜0.05).Conclusions The results suggested that rs501120 was tightly associated with CHD in people younger than 60 years or had diabetes.