CAJ | 학술논문

目的评估短暂性脑缺血发作(TIA)患者发生卒中的危险性及抗血小板剂的干预效果.方法 256例TIA患者随机分为干预组和对照组,各128例.对照组予一般措施及安慰剂,干预组在一般措施上加用氯吡格雷(75 me/d),并分别在发病后7 d、1、3、6个月比较两组卒中发病率、症状、体征和神经功能缺损评分情况,并监测血液流变学情况.结果对照组7 d、1、3,6个月时卒中发生率分别为8.59%.14.06%.21.09%和28.13%;干预组为0.00%,4.69%,8.59%和11.72%,两组存在显著差异(P＜0.05).干预组在研究后血液流变学改变、卒中患者病理征出现、脑梗死面积、神经功能缺损评分等方面,亦与对照组存在显著差异(P＜0.05).结论 TIA后卒中危险性比普通人群高得多,须及早二级预防,抗血小板药物效果确切,且安全.
목적 평고단잠성뇌결혈발작(TIA)환자발생졸중적위험성급항혈소판제적간예효과.방법 256례TIA환자수궤분위간예조화대조조,각128례.대조조여일반조시급안위제,간예조재일반조시상가용록필격뢰(75 me/d),병분별재발병후7 d、1、3、6개월비교량조졸중발병솔、증상、체정화신경공능결손평분정황,병감측혈액류변학정황.결과대조조7 d、1、3,6개월시졸중발생솔분별위8.59%.14.06%.21.09%화28.13%;간예조위0.00%,4.69%,8.59%화11.72%,량조존재현저차이(P＜0.05).간예조재연구후혈액류변학개변、졸중환자병리정출현、뇌경사면적、신경공능결손평분등방면,역여대조조존재현저차이(P＜0.05).결론 TIA후졸중위험성비보통인군고득다,수급조이급예방,항혈소판약물효과학절,차안전.
Objective To evaluate the risk of stxoke in patients after transient ischemic attack(TIA),and study the effect of intervention with antiplatelet drug.Methods 256 patients with TIA were randomly divided into intervention group and control group(128 in each group).All patients were treated with routine treatment,and in addition the antiplatelet dnlg(clopidogrel,75 mg/d)was added to the intervention group,placebo was added to the control group.After 7 days,1 month,3 months and 6 months,comparative analysis were made between two groups in incidence,clinical symptom,sign and neurological function defects scofe(with EdinburghScandina stroke scale.MESSS)of stroke patients.And the hemorheology indexeswere observed.Results After7 days.1 month.3 months and 6 months,the stroke incidences of control group were 8.59%,14.06%,21.09%and 28.13%.In intervention group.the incidences were 0.00%,4.69%,8.59%and 11.72%.The difference was,ignificant(P＜0.05).In pathological reflex,brain infarct area and MESSS of stroke patients,the differences were significant(P＜0.05)betweeen two groups.After treatment,there were also significant difference(P＜0.05)in hemorheology indexes of patients.Conclusion The stroke incidence of patients after TIA was significantly highter than general population,and Secondary Prevention of Stroke must be performed early.Antiplatelet drug is safe and effective for stroke prevention.