CAJ | 학술논문

目的研究肌萎缩侧索硬化与同型半胱氨酸水平的关系.方法采用断面研究,21例肌萎缩侧索硬化患者为ALS组,选取40例健康者为对照组,及检测两组患者的Hcy、叶酸、维生索B12,用高效液相色谱仪和荧光检测仪测定两组血浆总Hcy水平.结果 Hcy水平肌萎缩侧索硬化组17.65[17.65±11.23]μmol/L显著高于对照组10.32[10.32±6.72]μmoL/L;肌萎缩侧索硬化组[9.52±2.57]ng/mL叶酸水平明显低于对照组13.56[13.56±3.23]ng/mL;维生素B12水平在两组间无统计学差异(P＞0.05),肌萎缩侧索硬化组为(651±112.34)pg/mL,对照组为(632±164.89)pg/mL.结论 Hcy水平升高与肌萎缩侧索硬化密切相关,可能参与了肌萎缩侧索硬化的病理生理过程.
목적 연구기위축측색경화여동형반광안산수평적관계.방법 채용단면연구,21례기위축측색경화환자위ALS조,선취40례건강자위대조조,급검측량조환자적Hcy、협산、유생색B12,용고효액상색보의화형광검측의측정량조혈장총Hcy수평.결과 Hcy수평기위축측색경화조17.65[17.65±11.23]μmol/L현저고우대조조10.32[10.32±6.72]μmoL/L;기위축측색경화조[9.52±2.57]ng/mL협산수평명현저우대조조13.56[13.56±3.23]ng/mL;유생소B12수평재량조간무통계학차이(P＞0.05),기위축측색경화조위(651±112.34)pg/mL,대조조위(632±164.89)pg/mL.결론 Hcy수평승고여기위축측색경화밀절상관,가능삼여료기위축측색경화적병리생리과정.
Objective To examine the relationship between Hcy levels and clinical ALs.Methods In a cross-sectional study,21 amyotrophic lateral sclerosis patients were enrolled as ALS group and 40 healthy person as control group.The plasma Ievek of Hcy,B1,and fohte levels were measured in all subjects.Hcy levels were measured using highpefformance liquid chromatography with fluorescence detection.Results Patients with ALS had higher median plasma Hcy levels 17.65(17.65 ±11.23]us 10.32[10.32 4-6.72]μmol/L;P＜0.01)and lowerfolate levels9.52(9.52±2.57]us 13.56[13.56 4-3.23]ng/mL;P＜0.01),compared with controls.no significant difference was observed in plasma B12 levels between the two groups,651±112.34 pg/mL in ALS group,632±164.89 pg/mL in control group.Conclusion High plasma homocysteine(Hcy)levels was related with amyotrophic lateral sclerosis(ALS)compared with healthy controls and may be linked to pathophysiologic progression of the disease.