CAJ | 학술논문

目的探讨根除幽门螺杆菌对外周血白细胞和CRP的影响.方法回顾性分析158例幽门螺杆菌阳性患者经标准三联1周根除治疗后的临床资料,其中Hp根除组108例,Hp未根除组50例,观察两组患者治疗前及结束时、1个月、12个月外周血白细胞和CRP的变化.结果 108例成功根除Hp患者外周血白细胞、中性粒细胞和单核细胞明显减少,其CRP水平也较治疗前显著降低(P<0.05).但嗜酸性粒细胞、嗜碱性粒细胞、淋巴细胞计数则无显著变化(P>0.05).50例未根除Hp患者治疗前后上述参数均无明显变化(P>0.05).结论 Hp感染可导致外周血白细胞、中性粒细胞、单核细胞和CRP水平增加,表明Hp感染可能是一种全身性的炎性反应.
목적 탐토근제유문라간균대외주혈백세포화CRP적영향.방법회고성분석158례유문라간균양성환자경표준삼련1주근제치료후적림상자료,기중Hp근제조108례,Hp미근제조50례,관찰량조환자치료전급결속시、1개월、12개월외주혈백세포화CRP적변화.결과 108례성공근제Hp환자외주혈백세포、중성립세포화단핵세포명현감소,기CRP수평야교치료전현저강저(P<0.05).단기산성립세포、기감성립세포、림파세포계수칙무현저변화(P>0.05).50례미근제Hp환자치료전후상술삼수균무명현변화(P>0.05).결론 Hp감염가도치외주혈백세포、중성립세포、단핵세포화CRP수평증가,표명Hp감염가능시일충전신성적염성반응.
Objective To investigate the systemic effects of Helicobacter pylori (Hp) infection by comparing differential counts of leukocytes in peripheral blood and C-reactive protein (CRP) levels before and after eradication of Hp. Method A total of 158 Hp-positive patients underwent eradication by standard one-week triple therapy were divided into Hp eradicated group(n = 108) and Hp non-eradicated group(n = 50),the populations of peripheral blood leukocytes and CRP levels before and 0 (just after therapy),1 and 12 months after eradication were retrospectively analysed. Results In the eradicated group,blood leukecytes,neutrophils and monocytes decreased significantly after eradication,and the CRP levels were significantly lower than the levels before treatment (P < 0.05 ),but there was no significant change in eosinophils,basophils and lymphecytes (P > 0.05).In the non-eradicated group,there was no significant change in any studied pa-rameter (P > 0.05). Conclusion These findings suggest that Hp infection increase blood leukocytes,neu-trophil and monocyte counts in the peripheral blood and CRP levels,which indicates a significant role of Hp infection in systemic disorders.