CAJ | 학술논문

近年来研究表明,在维持肿瘤细胞的复制和增殖过程中端粒结构的完整性及其功能比端粒的长度有着更重要的作用,其中一种由6种端粒结合蛋白组成的端粒结合蛋白复合体在调节端粒酶活性、维持端粒长度和保护染色体末端起到重要作用,并且直接参与细胞有丝分裂进程的复杂调控.深入研究端粒结合蛋白复合体在肿瘤发病中的作用机制,对于寻求诊断和治疗的新途径具有十分重要的意义.
근년래연구표명,재유지종류세포적복제화증식과정중단립결구적완정성급기공능비단립적장도유착경중요적작용,기중일충유6충단립결합단백조성적단립결합단백복합체재조절단립매활성、유지단립장도화보호염색체말단기도중요작용,병차직접삼여세포유사분렬진정적복잡조공.심입연구단립결합단백복합체재종류발병중적작용궤제,대우심구진단화치료적신도경구유십분중요적의의.
Recent studies show that the structure integrality and function are more important than the length of telomere in maintaining tumor cells reproduction and proliferation.Mammalian telomeres bound by a specialized six-protein(TRF1,TRF2,TIN2,RAP1,POT1 and TPP1 )complex known as telosome or shelterin,has fundamental role in the regulation of telomere activity,maintaining the length and protecting telomere chromosome terminal.Telosome is involved in the complex regulation of cell mitosis process.The study of the role of telomere binding protein complex in tumorigenesis is very important for searching new methods of tumor diagnosis and treatment.