CAJ | 학술논문

茶多酚(tea polyphenols,TP)是绿茶中对人体有益的主要成分,其对多种不同类型的肿瘤发生可能具有防护作用,其中包括表遗传途径.表遗传指不改变DNA序列的情况下基因表达发生可遗传改变的机制,主要包括DNA甲基化、组蛋白修饰、染色质重塑、siRNA和miRNA调控等,在人类的大多数肿瘤中都观察到表修饰模式的异常.茶多酚具有抑制DNA甲基转移酶、改变组蛋白修饰和miRNA表达的生物学活性,对肿瘤的防护与治疗具有一定的价值.该文就茶多酚的表遗传机制的研究进展作一简要概述.
다다분(tea polyphenols,TP)시록다중대인체유익적주요성분,기대다충불동류형적종류발생가능구유방호작용,기중포괄표유전도경.표유전지불개변DNA서렬적정황하기인표체발생가유전개변적궤제,주요포괄DNA갑기화、조단백수식、염색질중소、siRNA화miRNA조공등,재인류적대다수종류중도관찰도표수식모식적이상.다다분구유억제DNA갑기전이매、개변조단백수식화miRNA표체적생물학활성,대종류적방호여치료구유일정적개치.해문취다다분적표유전궤제적연구진전작일간요개술.
Tea polyphenols (TP) is one of components from green teas, beneficial to human health. They may help prevent different types of tumors, and are involved in epigenetic pathway. Epigenetics is defined as reversible heritable changes in gene expression that occur without alteration in DNA sequence, including DNA methylation, histone modification, chromatin remodeling, and RNA interference.Most of tumors in humans have shown the abnormal patterns of epigenetics. Tea polyphenols demonstrated some effects of epigenetic agents, inducing epigenetic changes through modifying methylation, histone modifications and expression of some miRNAs. It has potential to be used as an agent for tunor prevention.