国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2008年
6期
517-519,523
,共4页
左西孟旦%钙增敏剂%正性肌力药%治疗应用
左西孟旦%鈣增敏劑%正性肌力藥%治療應用
좌서맹단%개증민제%정성기력약%치료응용
levosimendan%Ca2+ sensitizer%inotropic agents%therapeutic use
左西孟旦是一种新型正性肌力药--钙增敏剂,可通过钙敏作用增强心肌收缩力,激活K+通道使血管扩张,且并不增加心肌氧耗和心率,因而具有改善心功能和心肌保护等作用.可应用于治疗急性失代偿心力衰竭、心肌缺血后心脏收缩力异常、心肌顿抑以及用于心脏手术期间循环的调控等方面.
左西孟旦是一種新型正性肌力藥--鈣增敏劑,可通過鈣敏作用增彊心肌收縮力,激活K+通道使血管擴張,且併不增加心肌氧耗和心率,因而具有改善心功能和心肌保護等作用.可應用于治療急性失代償心力衰竭、心肌缺血後心髒收縮力異常、心肌頓抑以及用于心髒手術期間循環的調控等方麵.
좌서맹단시일충신형정성기력약--개증민제,가통과개민작용증강심기수축력,격활K+통도사혈관확장,차병불증가심기양모화심솔,인이구유개선심공능화심기보호등작용.가응용우치료급성실대상심력쇠갈、심기결혈후심장수축력이상、심기돈억이급용우심장수술기간순배적조공등방면.
Levosimendan, a new positive inotropic drug-Ca2+ sensitizer, enhances myocardial contractility by myocardial Ca2+sensitization and dilates blood vessel by activating potassium channels, without changes in oxygen consumption and heart rate. Therefore, levosimendan may improve myocardial performance and exerts cardioprotective effects. Levosimendan has been used in patients with acute decompensation of chronic heart failure, myocardial infarction, contractile dysfunction after myocardial stunning. It is also used to regulate circulation in cardiac surgery.
