CAJ | 학술논문

目的探讨非小细胞肺癌(NSCLC)患者血清中骨桥蛋白(OPN)水平及其临床意义.方法采用酶联免疫吸附法(ELISA)测定102例NSCLC患者和42例良性肺部疾病患者血清OPN水平,选取同期本院门诊健康体检30例正常人血清作为对照组,分析OPN与肺癌临床特征及预后的关系.结果 NSCLC患者血清OPN水平明显高于良性肺部疾病患者和健康对照组(P＜0.01).不同性别、年龄、病理类型和病理分级NSCLC患者之间血清OPN水平接近,差异均无统计学意义(P＞0.05).Ⅲ-Ⅳ期的患者血清OPN水平高于Ⅰ-Ⅱ期患者；有淋巴结转移患者高于无淋巴结转移的患者；手术前患者高于手术后患者；复发后患者明显高于复发前患者；存活期3年以上患者明显低于存活期3年以内患者,各组差异均有统计学意义(P＜0.01).结论血清OPN水平能够反映疾病的严重程度,其指标对判定手术效果、监测复发和评估预后等具有指导意义.
목적 탐토비소세포폐암(NSCLC)환자혈청중골교단백(OPN)수평급기림상의의.방법 채용매련면역흡부법(ELISA)측정102례NSCLC환자화42례량성폐부질병환자혈청OPN수평,선취동기본원문진건강체검30례정상인혈청작위대조조,분석OPN여폐암림상특정급예후적관계.결과 NSCLC환자혈청OPN수평명현고우량성폐부질병환자화건강대조조(P＜0.01).불동성별、년령、병리류형화병리분급NSCLC환자지간혈청OPN수평접근,차이균무통계학의의(P＞0.05).Ⅲ-Ⅳ기적환자혈청OPN수평고우Ⅰ-Ⅱ기환자；유림파결전이환자고우무림파결전이적환자；수술전환자고우수술후환자；복발후환자명현고우복발전환자；존활기3년이상환자명현저우존활기3년이내환자,각조차이균유통계학의의(P＜0.01).결론 혈청OPN수평능구반영질병적엄중정도,기지표대판정수술효과、감측복발화평고예후등구유지도의의.
Objective To explore the levels and clinical significance of osteopontin (OPN) in serum of patients with non-small cell lung cancer (NSCLC).Methods OPN levels of 102 cases of NSCLC,42 cases of benign lung disease and 30 cases of healthy control were measured by enzyme-linked immunosorbent assay(ELISA).Results The serum OPN levels of NSCLC were significantly higher than those of benign lung disease group and healthy control group (P＜0.01).The levels of OPN in serum were compared between different gender,age,histological differentiation and pathological type groups,but there were no significant difference (P＞0.05).The serum OPN levels of Ⅲ - Ⅳ stage NSCLC patients,with lymph node metastasis,before operation patients,recrudescent patients,survival below 3 years patients were relatively higher than that in the patients with Ⅰ - Ⅱ stage,without lymph node metastasis,after operation,no recrudescent,survival over 3 years patients,and the differences were significant (P＜0.01).Conclusions OPN levels in serum reflected the severity of the disease,which can be used to determine the effects of surgery and monitor recurrence and evaluate prognosis.