国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
2期
122-125
,共4页
蠲痹颗粒%寒湿痹阻型和肾气虚寒型%类风湿关节炎
蠲痺顆粒%寒濕痺阻型和腎氣虛寒型%類風濕關節炎
견비과립%한습비조형화신기허한형%류풍습관절염
Juanbi granulae%Cold dampness obstruction and kidney yang qi deficiency syndrome%Rheumatoid arthritis
目的 初步评价蠲痹颗粒对寒湿痹阻和肾气虚寒型类风湿关节炎(rheumatoid arthritis,RA)的临床疗效.方法 采用随机数字表法将全部RA患者随机分为治疗组80例,对照组40例.全部患者均口服甲氨蝶呤片,10 mg/次,1次/周.治疗组在此基础上口服蠲痹颗粒,15g/次,3次/d;对照组口服正清风痛宁缓释片,60 mg/次,2次/d.两组均治疗4周后统计疗效.结果 ①治疗组疗效总有效率为95.0％、对照组为85.0％,两组比较差异有统计学意义(U=-4.071,P＜0.05)；治疗组证候疗效总有效率为72.5％、对照组为37.5％,两组比较差异有统计学意义(U=-3.232,P＜0.05).②同组间疗效及证候疗效比较,差异均有统计学意义[(疾病疗效总有效率分别为100.0％、86.7％,U值分别为-5.50、-3.67,P＜0.01或0.05)；(证候疗效总有效率分别为88.0％、80.0％,U值分别为-2.909、一3.992,P均＜0.05)].③治疗后治疗组在改善ESR( 17.05±7.15) mrn/h、RF (32.46±14.22) U/L方面优于对照组(P均＜0.05).结论 蠲痹颗粒治疗寒湿痹阻和肾气虚寒型RA疗效确切,其中寒湿痹阻型RA疗效更明显.
目的 初步評價蠲痺顆粒對寒濕痺阻和腎氣虛寒型類風濕關節炎(rheumatoid arthritis,RA)的臨床療效.方法 採用隨機數字錶法將全部RA患者隨機分為治療組80例,對照組40例.全部患者均口服甲氨蝶呤片,10 mg/次,1次/週.治療組在此基礎上口服蠲痺顆粒,15g/次,3次/d;對照組口服正清風痛寧緩釋片,60 mg/次,2次/d.兩組均治療4週後統計療效.結果 ①治療組療效總有效率為95.0％、對照組為85.0％,兩組比較差異有統計學意義(U=-4.071,P＜0.05)；治療組證候療效總有效率為72.5％、對照組為37.5％,兩組比較差異有統計學意義(U=-3.232,P＜0.05).②同組間療效及證候療效比較,差異均有統計學意義[(疾病療效總有效率分彆為100.0％、86.7％,U值分彆為-5.50、-3.67,P＜0.01或0.05)；(證候療效總有效率分彆為88.0％、80.0％,U值分彆為-2.909、一3.992,P均＜0.05)].③治療後治療組在改善ESR( 17.05±7.15) mrn/h、RF (32.46±14.22) U/L方麵優于對照組(P均＜0.05).結論 蠲痺顆粒治療寒濕痺阻和腎氣虛寒型RA療效確切,其中寒濕痺阻型RA療效更明顯.
목적 초보평개견비과립대한습비조화신기허한형류풍습관절염(rheumatoid arthritis,RA)적림상료효.방법 채용수궤수자표법장전부RA환자수궤분위치료조80례,대조조40례.전부환자균구복갑안접령편,10 mg/차,1차/주.치료조재차기출상구복견비과립,15g/차,3차/d;대조조구복정청풍통저완석편,60 mg/차,2차/d.량조균치료4주후통계료효.결과 ①치료조료효총유효솔위95.0％、대조조위85.0％,량조비교차이유통계학의의(U=-4.071,P＜0.05)；치료조증후료효총유효솔위72.5％、대조조위37.5％,량조비교차이유통계학의의(U=-3.232,P＜0.05).②동조간료효급증후료효비교,차이균유통계학의의[(질병료효총유효솔분별위100.0％、86.7％,U치분별위-5.50、-3.67,P＜0.01혹0.05)；(증후료효총유효솔분별위88.0％、80.0％,U치분별위-2.909、일3.992,P균＜0.05)].③치료후치료조재개선ESR( 17.05±7.15) mrn/h、RF (32.46±14.22) U/L방면우우대조조(P균＜0.05).결론 견비과립치료한습비조화신기허한형RA료효학절,기중한습비조형RA료효경명현.
Objective To observe the effect of Juanbi granulae on rheumatoid arthritis belonging to cold dampness obstruction and kidney yang qi deficiency syndrome.Methods All 120 RA patients in accordance with the inclusion criteria were divided into a 80 cases of study group,and a 40 cases of control group,by random table method.Methotrexate,10mg once a week,was given orally,as a basis for treatment.The treatment group given Juanbi granulae,15g for each time,3 times a day; while the control group was Zhenqingfengtongning sustained-release tablets,60mg for each time,twice daily.Both groups have adopted a one-month course of treatment.Statistics effect was evaluated after 4-week course of treatment.Results ①There was significant difference between the two group in terms of therapeutic effects and symptom effects after the treatment (the total effective rate of study group and control group was 100.0％,86.7％,U value was-4.071,-3.232 respectively,P＜0.05).② The treatment effects and the symptom effect of the cold dampness syndrome and the kidney yang qi deficiency syndrome in the same group showed statistical difference after the treatment (the total effective rate of study group and control group was 88.0％,80.0％,The U value of treatment effect was-5.50,-3.67 respectively,P＜0.01 or P＜0.05).(U value of syndrome effect was-2.909,-3.992 respectively,P＜0.05).③ Study group of after treatment ESR (17.05±7.15) mm/h,RF (32.46± 14.22) U/L,compared with the control group of after treatment,the difference was statistically significant (P＜0.05).Conclusion Juanbi granulae was effective in treating rheumatoid arthritis of both kidney yang qi deficiency syndrome and cold dampness obstruction syndrome,the effects were especially better for cold dampness obstruction syndrome.
