CAJ | 학술논문

衰老是生物体随着时间的推移机体发生变化的累积过程,它对机体的许多系统都有功能上的影响,包括免疫系统.在过去的几十年里,以动物为模型研究衰老与固有免疫间的关系已十分普遍,但衰老对人固有免疫方面的研究却比较少.衰老影响人固有免疫细胞亚群(单核吞噬细胞,中性粒细胞,树突状细胞,自然杀伤细胞)的功能及数量,同样影响老年人抗感染和疫苗接种的效果.
쇠로시생물체수착시간적추이궤체발생변화적루적과정,타대궤체적허다계통도유공능상적영향,포괄면역계통.재과거적궤십년리,이동물위모형연구쇠로여고유면역간적관계이십분보편,단쇠로대인고유면역방면적연구각비교소.쇠로영향인고유면역세포아군(단핵탄서세포,중성립세포,수돌상세포,자연살상세포)적공능급수량,동양영향노년인항감염화역묘접충적효과.
Aging is the accumulation of changes in an organism or object over time which influence the function of many systems including immune system. In the past decades, the impact of aging on innate immunity, an important component of immune system, has been extensively studied in aging animal model, however little is known about human. Here we review current views about how aging may affect the innate immune cell subsets, includingmononuclear phagocyte, neutrophils , dendritic cells and natural killer in human immune system-with a focus on the response to infection or vaccination in old age.