CAJ | 학술논문

糖尿病性神经病理性疼痛(diabetic neuropathic pain,DNP)是糖尿病最常见的慢性并发症之一.其发病机制未明,至今仍缺乏疗效确切且安全的治疗方法.丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号转导通路是细胞外信号从细胞表面传导至细胞核内部的重要传递途径,在神经细胞的可塑性过程中发挥重要作用.糖尿病时,高血糖被认为是DNP发病的重要病理生理学基础,与其他因素一起激活MAPK信号转导通路,使神经元功能和结构发生可塑性改变,导致DNP的发生.
당뇨병성신경병이성동통(diabetic neuropathic pain,DNP)시당뇨병최상견적만성병발증지일.기발병궤제미명,지금잉결핍료효학절차안전적치료방법.사렬원활화단백격매(mitogen-activated protein kinases,MAPK)신호전도통로시세포외신호종세포표면전도지세포핵내부적중요전체도경,재신경세포적가소성과정중발휘중요작용.당뇨병시,고혈당피인위시DNP발병적중요병리생이학기출,여기타인소일기격활MAPK신호전도통로,사신경원공능화결구발생가소성개변,도치DNP적발생.
Diabetic neuropathic pain (DNP) is considered as one of the most common chronic complications of diabetes. We still do not understand its pathogeneses and also lack safe and effective therapeutic methods. Mitogen -activated protein kinases (MAPK) is an important transduction pathway in signals transmitted from extracellular to intracellular, and also plays a crucial role in neuronal plasticity. In diabetes, hyperglycosemia is considered as the main pathophysiologic basis of DNP by activation of MAPK signal transduction pathway along with other factors and by both eonstroctral and functional modifications in neuronal plasticity.