CAJ | 학술논문

证据表明小胶质细胞在神经病理性疼痛中扮演着重要的角色.神经损伤后,小胶质细胞内p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)激活,致小胶质细胞产生各种生物活性物质,引发痛觉超敏.小胶质细胞内p38MAPK在神经病理性疼痛的发生和发展中起重要作用,p38MAPK及其亚型有望成为治疗神经病理性疼痛的新靶点.
증거표명소효질세포재신경병이성동통중분연착중요적각색.신경손상후,소효질세포내p38사렬원활화단백격매(p38 mitogen activated protein kinase,p38MAPK)격활,치소효질세포산생각충생물활성물질,인발통각초민.소효질세포내p38MAPK재신경병이성동통적발생화발전중기중요작용,p38MAPK급기아형유망성위치료신경병이성동통적신파점.
Emerging evidences indicate that microglia plays a critical role in the pathogenesis of neuropathic pain. Previous evidences suggest that the activation of p38MAPK signaling pathway in hyperactive microglia in the dorsal horn of spinal cord in-volves in the neuropathic pain. Present findings shows that p38MAPK is activated in the spinal microglia after nerve injury and con-tributes importantly to the development and maintenance of neuropathic pain.