CAJ | 학술논문

目的验证新剂型阿苯达唑乳剂对肝囊型包虫病患者的临床疗效.方法对212例肝囊型包虫病患者用阿苯达唑10 mg/Kg/d 和12.5 mg/Kg/d两种剂量进行治疗.服药3个月复查一次为一个疗程,各疗程之间不间断连续用药.以B超影象特征为主判定疗效.观察不同疗程的效果.以停药时的检查结果为近期疗效.停药后随访1-4年的结果为远期疗效.结果两个剂量组共212例患者的平均近期疗效为:治愈率74.5%,有效率为99.1%,无效率为0.9% .平均远期疗效为:治愈率为83.1%,有效率为89.3%,无效率为0.6%,复发率为10.2% .以12.5 mg/Kg/d连续治疗9个月的疗效最好.复发病人再治疗的效果良好.结论阿苯达唑乳剂对肝囊型包虫病的临床疗效超过当前包虫病药物治疗的最好水平.且疗效稳定可靠,不良反应轻微.可做为包虫病首选治疗方法.
목적험증신제형아분체서유제대간낭형포충병환자적림상료효.방법대212례간낭형포충병환자용아분체서10 mg/Kg/d 화12.5 mg/Kg/d량충제량진행치료.복약3개월복사일차위일개료정,각료정지간불간단련속용약.이B초영상특정위주판정료효.관찰불동료정적효과.이정약시적검사결과위근기료효.정약후수방1-4년적결과위원기료효.결과량개제량조공212례환자적평균근기료효위:치유솔74.5%,유효솔위99.1%,무효솔위0.9% .평균원기료효위:치유솔위83.1%,유효솔위89.3%,무효솔위0.6%,복발솔위10.2% .이12.5 mg/Kg/d련속치료9개월적료효최호.복발병인재치료적효과량호.결론아분체서유제대간낭형포충병적림상료효초과당전포충병약물치료적최호수평.차료효은정가고,불량반응경미.가주위포충병수선치료방법.
Objective To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis.Methods Two regimens of AbzE (10 mg*kg-1*d-1 and 12.5 mg*kg-1*d-1) were given to 212 patients with liver cystic hydatidosis in courses ranging from 3 months to more than one year. Assessment of drug efficacy was essentially based on imaging signs with ultrasonography as the main tool. Assessments were performed at the end of different courses and in the follow-up study of 1-4 years after the cessation of therapy.Results At the end of therapeutic courses, the overall cure rate of the 212 cases was 74.5%, with a 99.1% effective rate. In the follow-up study, the cure rate was 83.l%, effective rate was 89.3%, ineffective rate was 0.6%, and recurrence rate was 10.2%. The highest cure rate was observed in cases receiving AbzE 12.5 mg*kg-1*d-1 for 9 months. Retreatment of recurrent cases with AbzE obtained satisfactory results.Conclusions AbzE surpassed other currently used antihydatidosis drugs or formulations with its promising efficacy and mild side effects, and could be recommended as a drug of choice in the treatment of cystic hydatidosis.