CAJ | 학술논문

目的　评价化学治疗药物(下称化疗药)在肝癌治疗中的作用和地位。　方法　采用MTT法测定5-Fu、顺铂和4-PA对肝癌细胞增殖的抑制作用。　结果　(1)5-Fu、顺铂两药分别单剂使用，在给药后0.5?h肝癌细胞增殖活跃，而12 ?h后肝癌细胞增殖均受到抑制；对氯苯乙酸在给药后0.5?h?肝癌细胞增殖即被抑制。(2)肝癌细胞抑制率随化疗药的作用时间延长而增加，48～72?h达50%以上的抑制率。（ 3）化疗药对肝癌细胞的作用早期，癌细胞的生长有返跳活跃阶段，但总体上癌细胞的生长被抑制。　结论　连续用药可很好地抑制肝癌细胞增殖，提高恶性肿瘤化学药物治疗的效果。
목적　평개화학치료약물(하칭화료약)재간암치료중적작용화 지위。　방법　 채용MTT법측정5-Fu、 순박화4-PA대간암세포증식적억제작용。　결과　(1)5-Fu、순박량약분별단제사용，재급약후0.5?h간암세포증식활약，이12 ?h후간암세포증식균수도억제；대록분을산재급약후0.5?h?간암세포증식즉피억 제 。(2)간암세포억제솔수화료약적작용시간연장이증가，48～72?h체50%이상적억제솔。（ 3）화료약대간암세포적작용조기，암세포적생장유반도활약계단，단총체상암세포적생장 피억제。　결론　 련속용약가흔호지억제간 암세포증식，제고악성종류화학약물치료적효과。
Objective　To evaluate the in vitro effect of che motherapeutant on hepatic carcinoma.　Methods　The inhibitory effect of 5-Fu, DDP and 4-PA on Bel-7402 cel ls proliferation was studied by MTT colorimetry.　Resu lts　(1) Bel-7402 was on an active proliferation by the treat ment of 5-Fu and DDP for half an hour, and the proliferation inhibited after 12 hours; but the proliferation was inhibited by 4-PA after half an hour of tr eatment. (2) The inhibitory rates increase with time and were over 50% after 48 ～72 hours of treatment. (3) There was temporarily active proliferation of Bel- 7402 cells in the early period of chemotherapy by 5-Fu and DDP. 　Conclusion　Continuous chemotherapy is effectiv e for the inhibition of Bel-7402 cells proliferation.