现代临床医学生物工程学杂志
現代臨床醫學生物工程學雜誌
현대림상의학생물공정학잡지
2001年
1期
9-11
,共3页
黄绍宽%陆益强%陈盛强%柳息洪%燕启江%刘利东%陈柏铭
黃紹寬%陸益彊%陳盛彊%柳息洪%燕啟江%劉利東%陳柏銘
황소관%륙익강%진성강%류식홍%연계강%류리동%진백명
载脂蛋白E Alzheimer病 基因多态性 聚合酶链反应-限制性片段长度多态性
載脂蛋白E Alzheimer病 基因多態性 聚閤酶鏈反應-限製性片段長度多態性
재지단백E Alzheimer병 기인다태성 취합매련반응-한제성편단장도다태성
目的 探讨Alzheimer病(Alzheimer disease,AD)患者的载脂蛋白E(apolipoproteinE,APOE)基因的分布,及其相关性.方法 利用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对AD患者和相应健康对照的APOE基因进行分型,从而进行AD与APOE等位基因多态性的关联分析.结果 AD病人APOE等位基因.ε4占20.74%,明显高于正常人对照组的7.64%,而ε3则占64.63%,低于正常人对照组的84.12%.结论 APOE等位基因中,ε4可能为AD的易患因子,而ε3则为保护因子
目的 探討Alzheimer病(Alzheimer disease,AD)患者的載脂蛋白E(apolipoproteinE,APOE)基因的分佈,及其相關性.方法 利用聚閤酶鏈式反應-限製性片段長度多態性(PCR-RFLP)技術對AD患者和相應健康對照的APOE基因進行分型,從而進行AD與APOE等位基因多態性的關聯分析.結果 AD病人APOE等位基因.ε4佔20.74%,明顯高于正常人對照組的7.64%,而ε3則佔64.63%,低于正常人對照組的84.12%.結論 APOE等位基因中,ε4可能為AD的易患因子,而ε3則為保護因子
목적 탐토Alzheimer병(Alzheimer disease,AD)환자적재지단백E(apolipoproteinE,APOE)기인적분포,급기상관성.방법 이용취합매련식반응-한제성편단장도다태성(PCR-RFLP)기술대AD환자화상응건강대조적APOE기인진행분형,종이진행AD여APOE등위기인다태성적관련분석.결과 AD병인APOE등위기인.ε4점20.74%,명현고우정상인대조조적7.64%,이ε3칙점64.63%,저우정상인대조조적84.12%.결론 APOE등위기인중,ε4가능위AD적역환인자,이ε3칙위보호인자
Objective To study the distribution of Apo E gene in patientswith Alzheimer desease, and analyse the relation between them . Methods ApoE genotyes of patients with Alzheimer desease and age-matched healthy controls were determined by using the polymerphism technique,subsequently to require the ralation between ApoE allele and AD . Results ApoE ε4 allele of patients with AD was 20.4%,which obviously was higher than 7.5% of cotrols, but ε3 allele of patients with AD was 64.8%, which was lower than 83.2% of cotrols.Conclusions In ApoE allele, ε4 allele is a genetic suscetible factor in AD,and ε3 allele is a protection factor.
