CAJ | 학술논문

Objective To investigate whether pretreatment with α1-antitrypsin (AAT) can attenuate acute lung injury (ALI) in rabbits induced with endotoxin.Results The infusion of endotoxin induced decreases in arterial oxygen pressure (PaO2), peripheral leukocyte counts, total respiratory compliance (TLC) and the increases in peak pressure (Ppeak), Qs/Qt compared with the baseline values (P<0.05). The increased plasma concentration but reduced activity of AAT was also found in contrast to that in Group NS (P<0.05). In the BALF, the activity of AAT, TPL, DSPC/TPL were lower than those in Group NS (P<0.05), but the concentrations of albumin, IL-8, TNFα, the activity of NE and the ratio of W/D were higher than those in Group NS (P<0.05). The pretreatment of AAT attenuated the deterioration of oxygenation, the reduction of compliance and the deterioration of other physiological and biochemical parameters mentioned above.Conclusion Pretreatment with AAT could attenuate endotoxin-induced lung injury in rabbits. Those beneficial effects of AAT might be due, in part, to reduction in the levels of mediators that could activate neutrophils, in addition to the direct inhibitory effect on neutrophil elastase.