CAJ | 학술논문

目的探讨缺血心肌灌注以及局部心肌的存活情况. 方法制备成功的10只猪心梗模型分别于术前及术后24 h、72 h及1周行MRI心肌首过灌注检查,MRI检查完后处死实验猪,行TTC染色及病理检查.结果符合实验研究10只猪术前MRI心肌首过期灌注未见灌注减低或缺损,术后8只见心肌灌注缺损和减低,灌注缺损区其灌注曲线未见明显的灌注峰,在正常心肌灌注峰值时间为低灌注表现,后期曲线呈逐渐上升表现;灌注缺损周围心肌其灌注曲线峰值信号强度低于正常侧壁和下壁心肌(P<0.05);灌注曲线峰值时间较正常侧壁和下壁心肌延迟(P<0.05).灌注缺损区TTC染色及病理均可见心肌坏死,灌注减低区见间质局灶水肿、心肌纤维水肿变性. 结论 MRI心肌首过灌注成像结合灌注曲线分析可以评价心肌活性和缺血情况.
목적 탐토결혈심기관주이급국부심기적존활정황. 방법 제비성공적10지저심경모형분별우술전급술후24 h、72 h급1주행MRI심기수과관주검사,MRI검사완후처사실험저,행TTC염색급병리검사.결과 부합실험연구10지저술전MRI심기수과기관주미견관주감저혹결손,술후8지견심기관주결손화감저,관주결손구기관주곡선미견명현적관주봉,재정상심기관주봉치시간위저관주표현,후기곡선정축점상승표현;관주결손주위심기기관주곡선봉치신호강도저우정상측벽화하벽심기(P<0.05);관주곡선봉치시간교정상측벽화하벽심기연지(P<0.05).관주결손구TTC염색급병리균가견심기배사,관주감저구견간질국조수종、심기섬유수종변성. 결론 MRI심기수과관주성상결합관주곡선분석가이평개심기활성화결혈정황.
Objective To explore the ischemic myocardial perfusion and viability.Methods Ten successful pigs with myocardial infarction model underwent MRI first-pass myocardial perfusion examinations preoperatively and 24 hours,72 hours and one week postoperation.After MRI examinations,the experimental pigs were executed and the samples underwent TTC staining and pathological examination.Results The preoperative myocardial perfusion in the all of the 10 pigs was nomal,but there were myocardial perfusion decrease and defects in 8 experimental pigs after operation,the perfusion curves in the area with perfusion defects had no obvious peak,but there was gradual increase in the end of the performance.The perfusion peak of the area with perfusion decrease was lower than that of normal inferior and lateral myocardial wall(P＜0.05) and the peak perfusion time was delayed compared with that of normal inferior and lateral myocardial wall (P＜0.05).There was myocardial necrosis in the perfusion defects areas that was certified by TTC staining and pathological examination.The intersititial edema and myocardial degeneration could be seen in the perfusion reduced areas.Conclusion MRI fist-pass myocardial perfusion imaging combined with perfusion curve analysis can evaluate the perfusion changes of the regional myocardial microcirculation.