CAJ | 학술논문

目的探讨广东籍病人原发性鼻咽癌(NPC)新的DNA拷贝数变化。方法用比较基因组杂交技术(CGH)检测17例原发性鼻咽癌遗传物质的增多和丢失情况。结果在半数以上病人中发现4q增多和1p丢失。此外，还发现其它一些较高频发生的新的基因组DNA 变化。结论广东原发性NPC的遗传学改变以4q、12q、1q增多和1p、3p、11q、14q、15q、13q、Xq、9q、10p、10q与16q 丢失为特点。这些发现可为下一步NPC相关基因的定位研究提供线索。
목적탐토엄동적병인원발성비인암(NPC)신적DNA고패수변화。방법용비교기인조잡교기술(CGH)검측17례원발성비인암유전물질적증다화주실정황。 결과재반수이상병인중발현4q증다화1p주실。차외，환발현기타일사교고빈발생적신적기인조DNA 변화。 결론엄동원발성NPC적유전학개변이4q、12q、1q증다화1p、3p、11q、14q、15q、13q、Xq、9q、10p、10q여16q 주실위특점。저사발현가위하일보NPC상관기인적정위연구제공선색。
Objective To gain a better understanding of genetic changes inCantonese nasopharyngeal carcinoma (NPC). Methods Comparative genomic hybridization (CGH) was performed on 17 primary nasopharyngeal carcinomas. Results A novel copy number gain an chromosome 4q and loss of chromosome 1p were found at a high frequency (>50%). Conclusions Current analysis revealed a comprehensive profile of the chromosomal regions showing gain of chromosomes 4q, 12q, and 1q as well as loss of chromosomes 1p, 3p, 11q, 14q, 15q, 13q, Xq, 9q, 10p, 10q, and 16q. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in the development of primary NPC.