CAJ | 학술논문

感觉分辨和情绪体验是疼痛的两个基本成分.痛的感觉分辨是对刺激的部位、强度和性质作出判断;痛情绪是疼痛刺激引起的不愉快或厌恶的情感体验.过去四十年间,对疼痛的感觉分辨成分在整体、细胞、分子和基因等各个层次上的研究取得了巨大的进展,然而,对痛的不愉快的情绪体验和相关的记忆究竟是怎样产生的,还知之甚少."只考虑痛的感觉特性而忽视其情绪情感特性,那只是看到问题的一部分,而且不是最重要的部分."越来越多的临床观察表明,慢性痛患者所遭受的恶性情绪,如焦虑、恐惧、孤独、甚至厌世等给病人造成的心身伤害远比疼痛本身更为严重.因此,对痛情绪和相关记忆形成机制的研究近年来逐步受到人们的关注.为进一步加深对疼痛本质的全面理解,本文简要综述了痛情绪和痛记忆的相关研究在神经解剖学、神经生理学和生物化学等方面的进展.
감각분변화정서체험시동통적량개기본성분.통적감각분변시대자격적부위、강도화성질작출판단;통정서시동통자격인기적불유쾌혹염악적정감체험.과거사십년간,대동통적감각분변성분재정체、세포、분자화기인등각개층차상적연구취득료거대적진전,연이,대통적불유쾌적정서체험화상관적기억구경시즘양산생적,환지지심소."지고필통적감각특성이홀시기정서정감특성,나지시간도문제적일부분,이차불시최중요적부분."월래월다적림상관찰표명,만성통환자소조수적악성정서,여초필、공구、고독、심지염세등급병인조성적심신상해원비동통본신경위엄중.인차,대통정서화상관기억형성궤제적연구근년래축보수도인문적관주.위진일보가심대동통본질적전면리해,본문간요종술료통정서화통기억적상관연구재신경해부학、신경생이학화생물화학등방면적진전.
The pain experience includes a sensory-discriminative and an emotional-affective component. The sensory dimension describes the quality, intensity, and spatio-temporal characteristics of the sensation. The affective dimension refers to the unpleasantness or aversion of sensation. The great progress at the genic, molecular, cellular, and systemic level on the study of the sensory dimension of pain has been made over past four decades. However, to consider only the sensory features of pain, and ignore its motivational and affective properties, is to look at only part of the problem. A line of clinic observations indicate that the patients with chronic pain suffer from much more affective disturbance than pain itself. Obviously, physiological arousal and hypervigilance to pain cause negative affect, such as fear, anxiety, angry, worry, aversion, even tendency of suicide, these negative affective states in turn enhance pain sensation. Therefore, the mechanisms underlying the affective dimension of pain have recently received more attention. In order to deepen and expand our understanding of the nature of pain, this review summarizes the main findings regarding affective component of pain in neuroanatomy, neurophysiology, and cell biochemistry