西安交通大学学报(英文版)
西安交通大學學報(英文版)
서안교통대학학보(영문판)
JOURNAL OF XI'AN MEDICAL UNIVERSITY
2004年
1期
42-44
,共3页
马欣%厉英倩%白宇飞%刘明
馬訢%厲英倩%白宇飛%劉明
마흔%려영천%백우비%류명
mercuric chloride (HgCl2)%thoracic aorta%calcium antagonist
Objective To explore the toxic effects of mercuric chloride (HgCl2) on vascular smooth muscle as well as its relationship to calcium antagonist. Methods By using isolated vascular tension methods, we studied the effect of HgCl2 on isolated rabbit aortic rings. Results HgCl2 (1-100μmol*L-1) caused a concentration-dependent contraction of rabbit aortic rings, which did not change with phentolamin or without endothelium. In KH solution with Ca2+ , the maximum contraction amplitude reduced by(61.2±3.3)%. Nifedipine produced a concentration-dependent decrease of the maximum contraction amplitude. Conclusion Calcium antagonist has protective effects on vascular smooth muscle against damage induced by HgCl2.
