CAJ | 학술논문

目的监测阴沟肠杆菌医院感染菌株ESBLs的产生及其对常用抗菌药物的耐药性。方法采用5种底物的“双纸片协同试验”检测ESBLs；体外药敏试验采用K-B法；实验数据处理使用WHONET-5软件。结果在本组样本的47株阴沟肠杆菌临床分离株中，ESBLs的检出率为38.3%；未发现亚胺培南耐药株，阿米卡星和环丙沙星的耐药率依次为17.0%、29.8%；产ESBLs和不产ESBLs菌株间的耐药率存在显著差异。结论ESBLs是造成本地区阴沟肠杆菌严重耐药的主要原因之一；阴沟肠杆菌感染的治疗应首选亚胺培南；其次为阿米卡星和环丙沙星。
목적감측음구장간균의원감염균주ESBLs적산생급기대상용항균약물적내약성。방법채용5충저물적“쌍지편협동시험”검측ESBLs；체외약민시험채용K-B법；실험수거처리사용WHONET-5연건。결과재본조양본적47주음구장간균림상분리주중，ESBLs적검출솔위38.3%；미발현아알배남내약주，아미잡성화배병사성적내약솔의차위17.0%、29.8%；산ESBLs화불산ESBLs균주간적내약솔존재현저차이。결론ESBLs시조성본지구음구장간균엄중내약적주요원인지일；음구장간균감염적치료응수선아알배남；기차위아미잡성화배병사성。
OBJECTIVE To determine the productive rates of extended-spectrumβ-lactamases (ESBLs) in the clinical isolates of Enterobacter cloacae,and investigate their resistance to 11 kinds of antibiotics.METHODS To detect ESBLs,47 strains of E.cloacae were determined by the double-disk synergy tests which placing disks of ceftazidime,cefotaxime,ceftriaxone,aztreonam,and cefepime at distance of 20 mm (center to center) from disk containing amoxicillin plus clavulanate.Antibiotic susceptibility test was performed by Kirby-Bauer disk diffusion method.The WHONET-5 software was used to analyze test results.RESULTS In this sample,the productive rate of ESBLs was 38.3%.ESBLs-producing strains had higher resistance rate than that of non-ESBLs-producing ones.The resistance rates of antibiotics that could be used in empiric therapy to deal with E.cloacae infection were imipenem(0),amikacin(17.0%),ciprofloxacin(29.8%) and cefepime(38.3%).CONCLUSIONS The antibiotic resistance of E.cloacae in our hospital was very serious,and ESBLs were one of the major mechanisms.Imipenem,amikacin and ciproflozacin were recommended in empiric therapy to deal with E.cloacae infections.