CAJ | 학술논문

目的评价腹腔注射善得定对大鼠腹部手术后肠粘连的预防作用。方法将50只SD大鼠随机分为5组：Ⅰ组，对照组；Ⅱ组，腹腔内注射善得定20 μg/kg；Ⅲ组，腹腔内注射善得定40 μg/kg；Ⅳ组，腹腔内注射善得定60 μg/kg；Ⅴ组，腹腔内注射透明质酸钠。各组动物均于术后14 d处死，肉眼评价粘连程度，并取粘连的肠段测羟脯氨酸（OHP）。结果Ⅱ，Ⅲ，Ⅳ，Ⅴ组之粘连程度明显低于Ⅰ组（P<0.05）；Ⅱ，Ⅲ，Ⅳ组粘连肠段的OHP明显低于Ⅰ组和Ⅴ组（P<0.05）；Ⅱ，Ⅲ，Ⅳ组间粘连程度及粘连肠段的OHP无明显差异（P>0.05）。结论腹腔注射善得定对预防腹部手术后肠粘连有一定作用。
목적평개복강주사선득정대대서복부수술후장점련적예방작용。방법장50지SD대서수궤분위5조：Ⅰ조，대조조；Ⅱ조，복강내주사선득정20 μg/kg；Ⅲ조，복강내주사선득정40 μg/kg；Ⅳ조，복강내주사선득정60 μg/kg；Ⅴ조，복강내주사투명질산납。각조동물균우술후14 d처사，육안평개점련정도，병취점련적장단측간포안산（OHP）。결과Ⅱ，Ⅲ，Ⅳ，Ⅴ조지점련정도명현저우Ⅰ조（P<0.05）；Ⅱ，Ⅲ，Ⅳ조점련장단적OHP명현저우Ⅰ조화Ⅴ조（P<0.05）；Ⅱ，Ⅲ，Ⅳ조간점련정도급점련장단적OHP무명현차이（P>0.05）。결론복강주사선득정대예방복부수술후장점련유일정작용。
Objective　To assess the efficacy of sandostatin in preventing postoperative adhesions in rats. Methods　Fifty SD rats were randomly divided into five groups: Group 1, Control group; group 2, sandostatin 20μg/kg intraperitoneal injection (IP); group 3, sandostastin 40μg/kg IP; group 4, sandostatin 60μg/kg IP; group 5, hyaluronate sodium(HA) IP. All animal were killed on the 14th postoperative day. After adhesions were graded according to their severity, adhesive ileal segments were resected for hydroxyproline(OHP) determination. Results　The severity of adhesions in group 2.3.4 and 5 were significantly milder than that in group 1.(P<0.05). The OHP levels of adhensive intestine in group 2.3 and 4 were significantly lower than that in group 1 and 5 (P<0.05).The severity of adhesions and OHP levels in group 2.3 and 4 had no significant difference (P>0.05). Conclusions　Intraperitoneal administration of sandostatin intraoperatively might have some efficacy in preventing adhensions of intestine.