CAJ | 학술논문

目的探索美沙酮与丁丙诺啡加洛非西定梯度治疗海洛因依赖戒断症状的疗效。方法将150例海洛因依赖者分为三组，每组50例，进行为期12 d的戒毒治疗，研究组采用美沙酮(总量80～110 mg)，丁丙诺啡(总量0.6～1.5 mg)。洛非西定(总量1.6 mg)治疗。美沙酮组(对照A组)采用美沙酮(总量139～175 mg)口服治疗；美沙酮加丁丙诺啡组(对照B组)，采用美沙酮(总量90～120 mg)，丁丙诺啡(总量0.9～2.3 mg)治疗。用统一的评定量表评定治疗结果。结果研究组在控制戒断症状、停药后无反跳现象、脱试率低、成瘾风险性小等方面均优于两个对照组。结论美沙酮加丁丙诺啡加洛非西定梯度治疗海洛因依赖戒断症状效果满意，是一种较好的戒毒方法。
목적탐색미사동여정병낙배가락비서정제도치료해락인의뢰계단증상적료효。방법장150례해락인의뢰자분위삼조，매조50례，진행위기12 d적계독치료，연구조채용미사동(총량80～110 mg)，정병낙배(총량0.6～1.5 mg)。락비서정(총량1.6 mg)치료。미사동조(대조A조)채용미사동(총량139～175 mg)구복치료；미사동가정병낙배조(대조B조)，채용미사동(총량90～120 mg)，정병낙배(총량0.9～2.3 mg)치료。용통일적평정량표평정치료결과。결과연구조재공제계단증상、정약후무반도현상、탈시솔저、성은풍험성소등방면균우우량개대조조。결론미사동가정병낙배가락비서정제도치료해락인의뢰계단증상효과만의，시일충교호적계독방법。
ObjectiveTo study the therapeutic effects of gradient treatment in heroin addiction withdrawal syndrome (HAWS) blocked by methadone, buprenorphine plus lofexidine. Method150 heroin addicts were divided into 3 groups and detoxification treatment was carried out for 12 days in each group (50 addicts). Group 1(Therapy study): total P.O. doses of 80～110 mg methadone plus 0.6～1.5 mg buprenorphine (im) and 1.6 mg lofexidine (P.O.)were administered; Group 2(Control A):a total P.O. dose of 139～175 mg methadone was given; Group 3(Control B): a combined therapy of 90～120 mg methadone (P.O.) plus 0.9～2.3 mg buprenorphine (im) was designed. The effects of treatment were scored according to the uniform scale tables. Results The therapeutic effects of Group 1 were more effective than those of both control groups in controlling the withdrawal syndrome, and no rebound phenomenon was found after withdrawal. Conclusion The effects of methadone combined with buprenorphine and lofexidine is satisfactory in blocking HAWS.