CAJ | 학술논문

目的：研究顺铂微晶口服后在小鼠体内的吸收分布和消除情况。方法：采用石墨炉原子吸收分光光度法，测定顺铂灌胃后在小鼠血液及不同脏器组织中的铂含量。结果：顺铂在小鼠血液、肝、胃、肾组织中均有分布，胃组织中顺铂的吸收更为明显，肾组织中顺铂有明显的积蓄。结论：顺铂微晶口服可以在胃组织中维持较高药浓，对治疗胃癌有进一步研究的意义，但其肾毒性不容忽视。
목적：연구순박미정구복후재소서체내적흡수분포화소제정황。방법：채용석묵로원자흡수분광광도법，측정순박관위후재소서혈액급불동장기조직중적박함량。결과：순박재소서혈액、간、위、신조직중균유분포，위조직중순박적흡수경위명현，신조직중순박유명현적적축。결론：순박미정구복가이재위조직중유지교고약농，대치료위암유진일보연구적의의，단기신독성불용홀시。
Objective:The absorbtion, distribution and elimination of microcrystalline cisplatin in mice by oral were studied. Methods:The levels of cisplatin in mice blood,liver,stomach and kidney were determined by Graphite Furnace Atomic Spectrophotometry after the administration of microcrystalline cisplatin. Results: The obvious distribution have been found in blood, liver, stomach and kidney, especially in stomach. The cisplatin could be stored up in kidney. Conclusion:The finding indicates that cisplatin may be adequate to treat stomach cancer orally, while its toxication on kidney should not be neglected.