CAJ | 학술논문

焦点粘着激酶是依赖于整合素的细胞信号转导通路的基础性信号传递分子.通过磷酸化酪氨酸位点和富脯氨酸序列，活化的焦点粘着激酶与细胞骨架蛋白、Src族激酶、磷酸肌醇-3激酶、Graf以及多种衔接子蛋白相互作用，调节细胞的粘附、迁移、增殖和分化.
초점점착격매시의뢰우정합소적세포신호전도통로적기출성신호전체분자.통과린산화락안산위점화부 포안산서렬，활화적초점점착격매여세포골가단백、Src족격매、린산기순-3격매、Graf이급다충함접자단백상 호작용，조절세포적점부、천이、증식화분화.
Focal adhesion kinase is a non-receptor protein tyrosine kinase with molecular weight 125 ku and regarded as the foundmental molecule of integrin-dependent signal transduction pathway. Active focal adhesion kinase regulates cell adhesion, migration, proliferation and differentiation by interacting with Src family kinase, phosphatidylinositol-3 kinase, cytoskeletal proteins, Graf and adoptor proteins through the phosphorylated tyrosines and the proline-rich sequences.