CAJ | 학술논문

目的:观察缺氧复氧对肾性高压(renal hypertension, RH)组及假手术(control, C)组大鼠血管舒缩反应的影响,并对其机制进行了初步探讨.方法:采用Goldblatt方法复制RH大鼠模型,并应用离体血管灌流方法观察血管舒缩反应的变化.结果:缺氧可引起对照组大鼠有内皮主动脉环产生一快速、短暂的额外收缩,随后舒张.复氧可使其先舒张、后收缩.RH组大鼠胸主动脉缺氧性收缩及复氧性舒张减弱,而随后的收缩增强.N-硝基-L-精氨酸甲基酯(N-nitro-L-arginine-methylester, L-NAME)可减弱缺氧收缩及复氧舒张、增强复氧收缩.超氧化物歧化酶(superoxide dismutase, SOD)可提高复氧舒张,减弱复氧收缩,RH组减弱明显.结论:RH组大鼠胸主动脉缺氧复氧舒缩反应变化与内皮分泌内皮源性舒张因子(endothelium-derived relaxing factor, EDRF)机制受损及自由基生成增多有关.
목적:관찰결양복양대신성고압(renal hypertension, RH)조급가수술(control, C)조대서혈관서축반응적영향,병대기궤제진행료초보탐토.방법:채용Goldblatt방법복제RH대서모형,병응용리체혈관관류방법관찰혈관서축반응적변화.결과:결양가인기대조조대서유내피주동맥배산생일쾌속、단잠적액외수축,수후서장.복양가사기선서장、후수축.RH조대서흉주동맥결양성수축급복양성서장감약,이수후적수축증강.N-초기-L-정안산갑기지(N-nitro-L-arginine-methylester, L-NAME)가감약결양수축급복양서장、증강복양수축.초양화물기화매(superoxide dismutase, SOD)가제고복양서장,감약복양수축,RH조감약명현.결론:RH조대서흉주동맥결양복양서축반응변화여내피분비내피원성서장인자(endothelium-derived relaxing factor, EDRF)궤제수손급자유기생성증다유관.