CAJ | 학술논문

目的探索聚乳酸作为软骨组织工程载体材料的可行性。观察4、8、12周后软骨缺损的情况，并对组织切片评分。方法制备了聚乳酸(PLA)多孔泡沫，将吸附骨髓基质细胞的聚乳酸多孔膜植入兔膝关节软骨负重(内髁)和非负重区(外髁)缺损内。结果骨髓基质细胞可以修复关节软骨缺损。结论聚乳酸是适合吸附骨髓基质细胞修复软骨的载体材料。
목적탐색취유산작위연골조직공정재체재료적가행성。관찰4、8、12주후연골결손적정황，병대조직절편평분。방법제비료취유산(PLA)다공포말，장흡부골수기질세포적취유산다공막식입토슬관절연골부중(내과)화비부중구(외과)결손내。결과골수기질세포가이수복관절연골결손。결론취유산시괄합흡부골수기질세포수복연골적재체재료。
Objective The foam of polylactic acid was prepared, the bone marrow stromal cells were absorbed by polylactic acid foam. Method We use the polylactic acid-cells complexes to repair the defects of rabbit articular cartilage in weight bearing and nonweight bearing area, to explore feasibility of polylactic acid as carrier materials in tissue engineering. After 4、8 、 12weeks the repair tissue was evaluated by histologic method. Result Bone marrow stromal cells are able to repair the detect of articular cartilage Conclusion The polylactic acid are fit carrier material for bone marrow stromal cell repair the detect of articular cartilage.