合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2009年
6期
744-746
,共3页
微波合成%脱保护%半胱氨酰甘氨酸
微波閤成%脫保護%半胱氨酰甘氨痠
미파합성%탈보호%반광안선감안산
microwave synthesis%de-protection%cysteinylglycine
微波条件下,溴化氢醋酸对S-苄基-N-苄氧羰基半胱氨酰甘氨酸乙酯(1)进行脱保护反应,合成了S-苄基半胱氨酰甘氨酸乙酯(2).最佳反应条件为:1 2.9 mmol,n(1):n(HBr-AcOH)=1:6,微波功率200 W,于30 ℃辐射20 min,2的收率为87%.其结构经~1H NMR和IR表征.
微波條件下,溴化氫醋痠對S-芐基-N-芐氧羰基半胱氨酰甘氨痠乙酯(1)進行脫保護反應,閤成瞭S-芐基半胱氨酰甘氨痠乙酯(2).最佳反應條件為:1 2.9 mmol,n(1):n(HBr-AcOH)=1:6,微波功率200 W,于30 ℃輻射20 min,2的收率為87%.其結構經~1H NMR和IR錶徵.
미파조건하,추화경작산대S-변기-N-변양탄기반광안선감안산을지(1)진행탈보호반응,합성료S-변기반광안선감안산을지(2).최가반응조건위:1 2.9 mmol,n(1):n(HBr-AcOH)=1:6,미파공솔200 W,우30 ℃복사20 min,2적수솔위87%.기결구경~1H NMR화IR표정.
S-benzylcysteinylglycine ethyl ester(2) was synthesized by de-protect reaction of S-benzyl-N-benzyloxycarbonyl-cysteinylglycine ethyl ester(1) with HBr-AcOH under microwave irradiation. The structure was confirmed by ~1H NMR and IR. The optimum reaction conditions at 30 ℃ for 20 min were as follows: 1 was 2.9 mmol; n(1) :n(HBr-AcOH) was 1:6； power was 200 W. The yield of 2 was 87% under the conditions.
