CAJ | 학술논문

目的探讨4',5,7-三羟基异黄酮对蛛网膜下腔出血(SAH)后的神经保护作用.方法对大鼠单次枕大池注血模型分别以10 mg/kg、50 mg/kg浓度腹腔注射4',5,7-三羟基异黄酮,观察大鼠脑水肿、血脑屏障(BBB)的通透性、氧化应激和血红素氧合酶-1(HO-1)的变化情况.结果 4',5,7-三羟基异黄酮可以减轻SAH后脑水肿,降低BBB通透性、缓解氧化应激状态及减少HO-1的表达.结论 4',5,7-三羟基异黄酮可能是通过提高内源性抗氧化酶的表达和抑制自由基的产生,从而在SAH中产生神经功能保护作用.
목적 탐토4',5,7-삼간기이황동대주망막하강출혈(SAH)후적신경보호작용.방법 대대서단차침대지주혈모형분별이10 mg/kg、50 mg/kg농도복강주사4',5,7-삼간기이황동,관찰대서뇌수종、혈뇌병장(BBB)적통투성、양화응격화혈홍소양합매-1(HO-1)적변화정황.결과 4',5,7-삼간기이황동가이감경SAH후뇌수종,강저BBB통투성、완해양화응격상태급감소HO-1적표체.결론 4',5,7-삼간기이황동가능시통과제고내원성항양화매적표체화억제자유기적산생,종이재SAH중산생신경공능보호작용.
Objective To evaluate the neuroprotective effects of genistein, a natural isoflavone compound, on subarachnoid hemorrhage (SAH) in rat model.Methods The SAH rat models were made by single blood injection into the cisterna magna and treated by intraperitoneal injection of genistein (10 or 50 mg/kg). Brain edema, blood brain barrier (BBB) permeability and the changes of oxidative stress and HO-1 expression were observed.Results The results showed that brain edema and BBB permeability were ameliorated by genistein. Genistein also increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased the malondialdehyde (MDA) level in the cerebral cortex of SAH rats. Furthermore, genistein significantly decreased the HO-1 expression which was induced by SAH.Conclusion Genistein may perform the neuroprotective effect after SAH by enhancing endogenous antioxidant enzymatic activities and inhibiting free radical generation.