CAJ | 학술논문

类风湿关节炎是一种累及关节的慢性自身免疫性疾病.蛋白质组学是研究细胞内所有蛋白质及其动态变化规律的科学.双向电泳、质谱技术和蛋白质信息学是蛋白质组学的三大支撑技术.近年来,类风湿关节炎在蛋白质组学方面的研究取得了一些新进展,应用蛋白质组学技术旨在从蛋白质水平研究疾病的发病机制,筛选出标志蛋白,从而协助疾病的诊断、治疗及判断预后.
류풍습관절염시일충루급관절적만성자신면역성질병.단백질조학시연구세포내소유단백질급기동태변화규률적과학.쌍향전영、질보기술화단백질신식학시단백질조학적삼대지탱기술.근년래,류풍습관절염재단백질조학방면적연구취득료일사신진전,응용단백질조학기술지재종단백질수평연구질병적발병궤제,사선출표지단백,종이협조질병적진단、치료급판단예후.
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting joints. Proteomics is a new field of studying the protein and its dynamic axiom of transmutation in cells. Two-dimensional gel electrophoresis, mass spectrometry and bioinformatics are the three major technology. Recently,the research in rheumatoid arthritis proteomics has made great progress. Application of proteomics technology is designed to study the pathogenesis from the proteins levels,finding out the marker proteins in order to improue RA diagnosis, treatment and prognosis.