目的 探讨中老年健康人群血尿酸升高的机制.方法 对1073例健康体检的中老年高尿酸患者的肾功能、空腹血糖、血脂等各项生化指标与同期1235例血尿酸正常的体检者进行对比分析.结果 高尿酸患者的血肌酐、尿素氮、空腹血糖、甘油三酯、总胆固醇各项指标均明显高于正常对照组(男性:t值或t′值分别为7.508、9.484、6.208、7.055、5.097,P均＜0.05;女性:t值或t′值分别为11.221、8.314、5.641、8.328、7.227,P均＜0.05).年龄分组后显示,男性正常对照组和高尿酸组各年龄组之间在尿素氮、空腹血糖、甘油三酯间差异有统计学意义(对照组:F值分别为3.500、5.607、3.378,P均＜0.05;高尿酸组:F值分别为15.400、5.111、11.143,P均＜0.05),而尿素氮、血肌酐、空腹血糖、甘油三酯的阳性率在各年龄组间有差异(对照组:χ2值分别为17.112、7.807、17.829、8.433,P均＜0.05;高尿酸组:χ2值分别为35.587、83.005、41.639、31.466,P均＜0.05),同年龄组间,高尿酸组尿素氮、血肌酐的平均值和阳性率都高于正常对照组(P均＜0.05),甘油三酯的平均值各年龄组均高于正常对照组(P＜0.05),而阳性率在≥70岁组差异无统计学意义(P＞0.05).空腹血糖和总胆固醇在低年龄组平均值和阳性率差异有统计学意义(P均＜0.05),而高年龄组差异无统计学意义(P＞0.05).女性正常对照组各统计指标在各年龄组间平均值和阳性率差异有统计学意义(尿素氮:F=13.759,χ2=19.491,P均＜0.05;空腹血糖:F=13.554,χ2=33.438,P均＜0.05;甘油三酯:F=18.160,χ2=16.978,P均＜o.05;总胆固醇:F=37.647,χ2=60.547,P均＜0.05),而高尿酸组只有尿素氮、血肌酐、总胆固醇的平均值和阳性率在各年龄组间有差异(尿素氮:F=5.830,χ2=11.941,P均＜0.05;血肌酐:F=4.057,χ2=20.097,P均＜0.05;总胆固醇:F=7.934,χ2=16.405,P均＜0.05),而同年龄组比较结果与男性相似.结论 中老年人群引起高尿酸的机制有差异,中年时期主要由于代谢紊乱引起,而老年时期主要由于肾功能减退引起.
目的 探討中老年健康人群血尿痠升高的機製.方法 對1073例健康體檢的中老年高尿痠患者的腎功能、空腹血糖、血脂等各項生化指標與同期1235例血尿痠正常的體檢者進行對比分析.結果 高尿痠患者的血肌酐、尿素氮、空腹血糖、甘油三酯、總膽固醇各項指標均明顯高于正常對照組(男性:t值或t′值分彆為7.508、9.484、6.208、7.055、5.097,P均＜0.05;女性:t值或t′值分彆為11.221、8.314、5.641、8.328、7.227,P均＜0.05).年齡分組後顯示,男性正常對照組和高尿痠組各年齡組之間在尿素氮、空腹血糖、甘油三酯間差異有統計學意義(對照組:F值分彆為3.500、5.607、3.378,P均＜0.05;高尿痠組:F值分彆為15.400、5.111、11.143,P均＜0.05),而尿素氮、血肌酐、空腹血糖、甘油三酯的暘性率在各年齡組間有差異(對照組:χ2值分彆為17.112、7.807、17.829、8.433,P均＜0.05;高尿痠組:χ2值分彆為35.587、83.005、41.639、31.466,P均＜0.05),同年齡組間,高尿痠組尿素氮、血肌酐的平均值和暘性率都高于正常對照組(P均＜0.05),甘油三酯的平均值各年齡組均高于正常對照組(P＜0.05),而暘性率在≥70歲組差異無統計學意義(P＞0.05).空腹血糖和總膽固醇在低年齡組平均值和暘性率差異有統計學意義(P均＜0.05),而高年齡組差異無統計學意義(P＞0.05).女性正常對照組各統計指標在各年齡組間平均值和暘性率差異有統計學意義(尿素氮:F=13.759,χ2=19.491,P均＜0.05;空腹血糖:F=13.554,χ2=33.438,P均＜0.05;甘油三酯:F=18.160,χ2=16.978,P均＜o.05;總膽固醇:F=37.647,χ2=60.547,P均＜0.05),而高尿痠組隻有尿素氮、血肌酐、總膽固醇的平均值和暘性率在各年齡組間有差異(尿素氮:F=5.830,χ2=11.941,P均＜0.05;血肌酐:F=4.057,χ2=20.097,P均＜0.05;總膽固醇:F=7.934,χ2=16.405,P均＜0.05),而同年齡組比較結果與男性相似.結論 中老年人群引起高尿痠的機製有差異,中年時期主要由于代謝紊亂引起,而老年時期主要由于腎功能減退引起.
목적 탐토중노년건강인군혈뇨산승고적궤제.방법 대1073례건강체검적중노년고뇨산환자적신공능、공복혈당、혈지등각항생화지표여동기1235례혈뇨산정상적체검자진행대비분석.결과 고뇨산환자적혈기항、뇨소담、공복혈당、감유삼지、총담고순각항지표균명현고우정상대조조(남성:t치혹t′치분별위7.508、9.484、6.208、7.055、5.097,P균＜0.05;녀성:t치혹t′치분별위11.221、8.314、5.641、8.328、7.227,P균＜0.05).년령분조후현시,남성정상대조조화고뇨산조각년령조지간재뇨소담、공복혈당、감유삼지간차이유통계학의의(대조조:F치분별위3.500、5.607、3.378,P균＜0.05;고뇨산조:F치분별위15.400、5.111、11.143,P균＜0.05),이뇨소담、혈기항、공복혈당、감유삼지적양성솔재각년령조간유차이(대조조:χ2치분별위17.112、7.807、17.829、8.433,P균＜0.05;고뇨산조:χ2치분별위35.587、83.005、41.639、31.466,P균＜0.05),동년령조간,고뇨산조뇨소담、혈기항적평균치화양성솔도고우정상대조조(P균＜0.05),감유삼지적평균치각년령조균고우정상대조조(P＜0.05),이양성솔재≥70세조차이무통계학의의(P＞0.05).공복혈당화총담고순재저년령조평균치화양성솔차이유통계학의의(P균＜0.05),이고년령조차이무통계학의의(P＞0.05).녀성정상대조조각통계지표재각년령조간평균치화양성솔차이유통계학의의(뇨소담:F=13.759,χ2=19.491,P균＜0.05;공복혈당:F=13.554,χ2=33.438,P균＜0.05;감유삼지:F=18.160,χ2=16.978,P균＜o.05;총담고순:F=37.647,χ2=60.547,P균＜0.05),이고뇨산조지유뇨소담、혈기항、총담고순적평균치화양성솔재각년령조간유차이(뇨소담:F=5.830,χ2=11.941,P균＜0.05;혈기항:F=4.057,χ2=20.097,P균＜0.05;총담고순:F=7.934,χ2=16.405,P균＜0.05),이동년령조비교결과여남성상사.결론 중노년인군인기고뇨산적궤제유차이,중년시기주요유우대사문란인기,이노년시기주요유우신공능감퇴인기.
Objective To study the mechanism of the hyperuricemia among the middle and elderly populations. Methods Serum uric acid, creatinine (Cr), blood urea nitrogen (BUN), fasting gluose (FG), total cholesterol (TC), triglyceride (TG) were detected in 1073 subjects with hyperuricemia and 1235 subjects with normal serum uric acid as control of middle and elder groups. Results The means of Cr, BUN, FG, TG ,TC in hyperuricemia were significantly higher than those in the control group,respectively (males: t′ =7. 508,P ＜0.05;t′ =9. 484,P ＜0.05;t=6.208,P＜0.05;t′ =7.055,P ＜0.05;t = 5. 097,P ＜0.05;females;t′ = 11.221,P ＜0.05;t′= 8.314,P ＜0.05 ;t =5. 641 ,P ＜0.05 ;t′ =8. 328 ,P ＜0.05 ;t =7. 227 ,P ＜ 0.05). In males,the mean of the BUN; FG and TG were significant different among the different age groups (the control group: F = 3. 500, P ＜ 0.05; F = 5. 607, P ＜0.05 ;F =3. 378,P ＜0.05 ;the hyperuricemia group: F= 15.400,P ＜0.05 ;F =5. 111 ,P ＜0.05 ;F = 11. 143 ,P ＜0.05), the positive rate of BUN, Cr, FG and TG were significant different among the different age groups (control group:χ2 = 17. 112,P ＜ 0.05;χ2 =7. 807,P ＜0.05 ;χ2 = 17. 829,P ＜0.05;χ2=8.433,P ＜0.05; hyperuricemia group:χ2 =35. 587,P ＜0.05 ;χ2 =83. 005 ,P ＜0.05 ;χ2 =41. 639,P ＜0.05 ;χ2 =31. 466,P ＜0.05). In the same age group,the mean and the positive rate of BUN and Cr were significantly higher in the hyperuricemia group than in the control group(P ＜ 0.05). The mean of TG was significantly higher in every age group of the hyperuricemia group than controls (P ＜ 0.05), but the positive rate had no significant differences in the age group of ≥ 70 years (P ＞0.05). The mean and the positive rate of FG and TC were significant differences in middle age group between the hyperuricemia and the control group (P ＜ 0.05), but were no differences in elder age group(P ＞ 0.05). In females,the mean and positive rate of Cr, BUN, FG,TG and TC were significant different in different age groups of the controls(BUN:F = 13. 759,P ＜0.05;χ2 = 19. 491 ,P ＜0.05; FG: F = 13. 554,P ＜0.05;χ2 = 33. 438,P ＜0.05;TG:F= 18. 160,P ＜0.05;χ2 = 16. 978,P ＜0.05;TC: F = 37. 647,P ＜0.05;χ2 =60.547,P ＜0.05) ,but in the hyperuricemia group that were only significant difference in BUN, Cr and TC (BUN:F = 5. 830, P ＜ 0.05; χ2 =11.941,P＜0.05;Cr:F=4.057,P ＜0.05;χ2 =20.097,P＜0.05;TC:F=7.934,P ＜0.05;χ2 = 16.405,P ＜0.05). In same age group compared of all the indices were similar with male. Conclusions The mechanism of serum uric acid increasing are different in middle age and elderly age. In middle age, it is metabolic disturbance. However,in elderly age it is descending of the kidney function.
