CAJ | 학술논문

目的探索孕产妇合并重型甲型H1N1流感的临床特点、诊治经验及对新生儿的影响.方法对我院2009年11-12月收治的11例重型甲型H1N1流感孕产妇患者(危重症3例)的临床资料进行回顾性分析.结果 11例患者均存在发热咳嗽症状,体温38.7～39.6℃,持续3～14 d.淋巴细胞降低9例,中性粒细胞比例增高9例,C反应蛋白均增高(12～129 mg/L),低蛋白血症者9例(22.4～30.2 mg/L).11例胸部影像学均提示两肺广泛片状密度增高,经神经氨酸酶抑制剂抗病毒、抗细菌感染和(或)综合治疗,10例痊愈、1例好转出院,9例孕妇患者均继续妊娠.仅1例新生儿败血症经治疗已痊愈,余新生儿及胎儿情况良好.结论孕产妇感染甲型H1N1流感易发展为重症,及时抗病毒抗菌、辅助支持治疗很重要,继续妊娠多数是安全的,但对新生儿的影响还有待进一步探讨.
목적 탐색잉산부합병중형갑형H1N1류감적림상특점、진치경험급대신생인적영향.방법 대아원2009년11-12월수치적11례중형갑형H1N1류감잉산부환자(위중증3례)적림상자료진행회고성분석.결과 11례환자균존재발열해수증상,체온38.7～39.6℃,지속3～14 d.림파세포강저9례,중성립세포비례증고9례,C반응단백균증고(12～129 mg/L),저단백혈증자9례(22.4～30.2 mg/L).11례흉부영상학균제시량폐엄범편상밀도증고,경신경안산매억제제항병독、항세균감염화(혹)종합치료,10례전유、1례호전출원,9례잉부환자균계속임신.부1례신생인패혈증경치료이전유,여신생인급태인정황량호.결론 잉산부감염갑형H1N1류감역발전위중증,급시항병독항균、보조지지치료흔중요,계속임신다수시안전적,단대신생인적영향환유대진일보탐토.
Objective To study the clinical characteristics and therapeutic effect of pregnant women infected with severe influenza A(H1N1), to survey the disease effects for the newborns. Methods The clinical data of 11 pregnant women infected with influenza A(H1N1 ) in our hospital from November to December 2009 were analyzed retrospectively. Results All the cases were in serious conditions, and 3 cases were in critical. All the patients were with symptoms of fever and cough, the temperature were in 38.7-39.6 ℃, and duration were 3-14 days. There were 9 cases with low lymphocytes, and 9 cases with high WBC. CRP were elevated in all the cases ( 12-129 mg/L), 9 cases were with hypochromia (22.4-30.2 mg/L). X ray showed increases of pulmonary hilar density for all the cases. By comprehensive treatment, 10 patients were cured and one showed marked progress. 9 cases continued pregnacy. One infant with septicemia was cured, other newborns and fetus were in good condition. Conclusions Pregnant women infected with influenza A (H1N1) are likely to develop severe condition. It is important to use antiviral treatment promptly,supplementary comprehensive treatment. Continuing pregnancy is safe, but the outcome to newborn needs further study.