CAJ | 학술논문

目的探讨代谢综合征(MS)不同组分、聚集数目及聚集方式与女性亚临床期颈动脉粥样硬化的关系,为心脑血管疾病防治提供更多信息.方法整群抽取3个事业单位女性体检人群835例,按照ATPⅢ标准定义MS.按年龄分组为25岁～、45岁～、65岁～;根据MS五个组分的聚集数目分为0、1、2、3、4、5组;再按照MS组分不同聚集方式分为16组;对上述各组人群行颈动脉超声检查,以颈动脉中内膜增厚和粥样斑块形成作为亚临床期颈动脉粥样硬化评价指标,比较MS各组分,各组分不同的聚集数目及不同的聚集方式对亚临床期颈动脉粥样硬化的影响.结果 MS总患病率27.8%,五个组分异常率分别为中心性肥胖69.3%,高血压31.0%,高密度脂蛋白胆固醇减低31.0%,高三酰甘油血症21.4%,高血糖18.1%.结果显示,中心性肥胖、高血压、低高密度脂蛋白胆固醇致颈动脉粥样硬化风险最强.随着组分聚集数目增加,颈动脉粥样硬化检出率不同程度增加,与0个组分相比,分别具有1、2、3、4、5个组分者患动脉粥样硬化的风险分别是0个组分的1.4倍、2.0倍、3.4倍、5.7倍及7.1倍;MS各组分不同的聚集方式对颈动脉粥样硬化产生不同的影响,常见的聚集方式为含有中心性肥胖组分与其他各组分的聚集.结论 MS每一组分均是亚临床期颈动脉粥样硬化的独立危险因素;随着组分聚集数目增加颈动脉粥样硬化患病风险成算术级别增加;MS各组分不同的聚集方式对颈动脉粥样硬化产生显著影响.
목적 탐토대사종합정(MS)불동조분、취집수목급취집방식여녀성아림상기경동맥죽양경화적관계,위심뇌혈관질병방치제공경다신식.방법 정군추취3개사업단위녀성체검인군835례,안조ATPⅢ표준정의MS.안년령분조위25세～、45세～、65세～;근거MS오개조분적취집수목분위0、1、2、3、4、5조;재안조MS조분불동취집방식분위16조;대상술각조인군행경동맥초성검사,이경동맥중내막증후화죽양반괴형성작위아림상기경동맥죽양경화평개지표,비교MS각조분,각조분불동적취집수목급불동적취집방식대아림상기경동맥죽양경화적영향.결과 MS총환병솔27.8%,오개조분이상솔분별위중심성비반69.3%,고혈압31.0%,고밀도지단백담고순감저31.0%,고삼선감유혈증21.4%,고혈당18.1%.결과 현시,중심성비반、고혈압、저고밀도지단백담고순치경동맥죽양경화풍험최강.수착조분취집수목증가,경동맥죽양경화검출솔불동정도증가,여0개조분상비,분별구유1、2、3、4、5개조분자환동맥죽양경화적풍험분별시0개조분적1.4배、2.0배、3.4배、5.7배급7.1배;MS각조분불동적취집방식대경동맥죽양경화산생불동적영향,상견적취집방식위함유중심성비반조분여기타각조분적취집.결론 MS매일조분균시아림상기경동맥죽양경화적독립위험인소;수착조분취집수목증가경동맥죽양경화환병풍험성산술급별증가;MS각조분불동적취집방식대경동맥죽양경화산생현저영향.
Objective To investigate the relationship between metabolic syndrome (MS) and female subclinical carotid atherosclerosis. Methods A total of 835 female subjects were enrolled in this study. MS was defined based on the ATP Ⅲ criteria. Age groups were ＜45,45 to 65,and ≥65 years. The participants were evaluated by the number of components of MS and clusters of MS components. Measurement of carotid arteries with B-mode ultrasound imaging was performed. Intima-media thickness and plague of the carotid arteries were regarded as the indicators of subclinical carotid atherosclerosis. Results The prevalence of carotid atherosclerosis, MS components and MS was significantly increased with the increased age. After age was adjusted, multiple logistic regression analysis showed that every component of MS was independently associated with carotid atherosclerosis; the increased waist circumstance and blood pressure and reduced HLD showed stronger effect. The prevalence of carotid atherosclerosis was increased with increasing number of components of MS. When compared to the 0 MS component group,the odds ratio (OR)of carotid atherosclerosis of the groups with 1, 2,3,4, or 5 components were 1.4,2. 0,3.4,5. 7 and 7. 1,respectively. The altered cluster components of MS impacted differently on carotid atherosclerosis. The clusters of components of MS with increased waist circumstance were more frequent than without ones. Conclusion Every component of MS may be an independent risk factor of carotid atherosclerosis;increased components of MS could contribute higher odd risk to carotid atherosclerosis; clusters of MS components might show different impacts on carotid atherosclerosis.