中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2012年
1期
75-78
,共4页
腺苷%Regadenoson%心肌缺血%放射性核素显像
腺苷%Regadenoson%心肌缺血%放射性覈素顯像
선감%Regadenoson%심기결혈%방사성핵소현상
Adenosine%Regadenoson%Myocardial ischemia%Radionuclide imaging
腺苷负荷试验心肌灌注显像诊断冠心病的价值已经得到公认,但其不良反应发生率较高.与腺苷相比,选择性A2a受体激动剂,如regadenoson具有独特优势,目前已完成Ⅲ期临床试验,有可能代替腺苷作为新的负荷试验药物.笔者对腺苷及选择性A2a受体激动剂regadenoson心肌负荷试验作一综述.
腺苷負荷試驗心肌灌註顯像診斷冠心病的價值已經得到公認,但其不良反應髮生率較高.與腺苷相比,選擇性A2a受體激動劑,如regadenoson具有獨特優勢,目前已完成Ⅲ期臨床試驗,有可能代替腺苷作為新的負荷試驗藥物.筆者對腺苷及選擇性A2a受體激動劑regadenoson心肌負荷試驗作一綜述.
선감부하시험심기관주현상진단관심병적개치이경득도공인,단기불량반응발생솔교고.여선감상비,선택성A2a수체격동제,여regadenoson구유독특우세,목전이완성Ⅲ기림상시험,유가능대체선감작위신적부하시험약물.필자대선감급선택성A2a수체격동제regadenoson심기부하시험작일종술.
Adenosine pharmacological myocardial stress test has been widely used in clinic.However,the side effects related with adenosine administration has been an issue of controversy.Current Phase Ⅲ study of regadenoson,a selective A2a receptor agonist,reveals its potential to substitute adenosine as a new agent for pharmacological myocardial stress test.This review briefs adenosine and regadenoson and their clinical utilities in myocardial stress test.
