CAJ | 학술논문

目的:探讨载脂蛋白E基因型与2型糖尿病的易感性.方法:应用multi ARMS 快速分型法对316例T2DM患者、512例健康对照人群的ApoE基因第4外显子112位Cys/Arg和158位Arg/Cys 进行检测;随机抽取分型标本进行DNA测序法验证.结果:ε2/2、ε2/3、ε3/3、ε4/2、ε4/3、ε4/4基因型在二组中的频率分布为:0.6%, 5.7%, 72.8%, 1.9%, 14.9%, 4.1% (T2DM组); 0.6%, 9.4%, 70.1%, 1.8%, 17.0%, 1.2% (对照组).二组间差异有显著性统计学意义(χ 2=11.45,P＜0.05), T2DM组ε4/4基因型频率明显高于对照组(4.11% VS 1.17%).结论:ApoEε4/4基因型可能与T2DM的易感性有关.
목적:탐토재지단백E기인형여2형당뇨병적역감성.방법:응용multi ARMS 쾌속분형법대316례T2DM환자、512례건강대조인군적ApoE기인제4외현자112위Cys/Arg화158위Arg/Cys 진행검측;수궤추취분형표본진행DNA측서법험증.결과:ε2/2、ε2/3、ε3/3、ε4/2、ε4/3、ε4/4기인형재이조중적빈솔분포위:0.6%, 5.7%, 72.8%, 1.9%, 14.9%, 4.1% (T2DM조); 0.6%, 9.4%, 70.1%, 1.8%, 17.0%, 1.2% (대조조).이조간차이유현저성통계학의의(χ 2=11.45,P＜0.05), T2DM조ε4/4기인형빈솔명현고우대조조(4.11% VS 1.17%).결론:ApoEε4/4기인형가능여T2DM적역감성유관.