CAJ | 학술논문

目的:观察地榆升白片预防性治疗干扰素所致白细胞减少的临床疗效.方法:112 例干扰素治疗慢性乙型肝炎患者,随机分为地榆升白片组、利血生组,分别于干扰素治疗前7 d开始服用地榆升白片或利血生,然后检测每组患者干扰素治疗后3 d,7 d、10 d、14 d、28 d的外周血细胞数值,观察地榆升白片预防性用药患者的血细胞数值的变化情况.结果:干扰素治疗3 d两组患者的外周血中性粒细胞均数分别为(1.91±0.56)×10~9/L、(1.48±0.55)×10~9/L,白细胞均数分别为(3.91±0.33)×10~9/L、(3.16±0.49)×10~9/L,其间差异有统计学意义(P<0.05).结论:地榆升白片预防性用药对于治疗干扰素所致白细胞减少有效,地榆升白片治疗是一种安全、经济、方便的预防干扰素所致白细胞减少的有效约物.
목적:관찰지유승백편예방성치료간우소소치백세포감소적림상료효.방법:112 례간우소치료만성을형간염환자,수궤분위지유승백편조、리혈생조,분별우간우소치료전7 d개시복용지유승백편혹리혈생,연후검측매조환자간우소치료후3 d,7 d、10 d、14 d、28 d적외주혈세포수치,관찰지유승백편예방성용약환자적혈세포수치적변화정황.결과:간우소치료3 d량조환자적외주혈중성립세포균수분별위(1.91±0.56)×10~9/L、(1.48±0.55)×10~9/L,백세포균수분별위(3.91±0.33)×10~9/L、(3.16±0.49)×10~9/L,기간차이유통계학의의(P<0.05).결론:지유승백편예방성용약대우치료간우소소치백세포감소유효,지유승백편치료시일충안전、경제、방편적예방간우소소치백세포감소적유효약물.
AIM: To observe effect of Diyu Shengbai Tablet on preventive treatment for interferon-induced leu-kopenia. METHODS: One hundred and twelve patients with chronic hepatitis B treated by IFN were randomly as-signed into two groups, and they were respectively treated with Diyu Shengbai Tablet and Leucogen for 7 days before treatment by IFN. The leukocyte count of each group was done in 3 days,7 days, 10 days, 14 days,28 days after treatment by IFN. Comparison was made on the value of leukocytes between two preventive treatment groups. RE-SULTS: In the third day after treatment by IFN the value of ANC were(1.91±0.56)×10~9/L, (1.48±0.55)× 10~9/L respectively. The value of leukocytes were (3.91±0.33)×10~9/L, (3.16±0.49)×10~9/L respectively. They had the statistical difference (P<0.05). CONCLUSION: Diyu Shengbai Tablet has an effect on preventing lekopenia induced by IFN, and it is a safe, cheap and convenient drug to treat leucopenia by IFN.