CAJ | 학술논문

T细胞辅助B细胞产生抗体是胸腺依赖抗原诱导体液免疫应答的一种基本方式.以往的观念认为,在该过程中发挥关键作用的是Th2细胞,但是最近一群新的T细胞亚群:TFH的发现可能改变了这一概念.TFH是一群属于CD4+T细胞的新的细胞亚群,在其分化发育过程中,IL-21发挥了关键作用,成熟的TFH细胞定位于生发中心,表面特异性标志为CD4+CXCR5+,可分泌IL-21等多种细胞因子.其中IL-21在自身免疫病、免疫缺陷病及肿瘤中都起重要的作用.T+细胞的发现丰富了人们对CD4+T细胞亚群的认识,拓展了对各种免疫性疾病的发病机制的认识.
T세포보조B세포산생항체시흉선의뢰항원유도체액면역응답적일충기본방식.이왕적관념인위,재해과정중발휘관건작용적시Th2세포,단시최근일군신적T세포아군:TFH적발현가능개변료저일개념.TFH시일군속우CD4+T세포적신적세포아군,재기분화발육과정중,IL-21발휘료관건작용,성숙적TFH세포정위우생발중심,표면특이성표지위CD4+CXCR5+,가분비IL-21등다충세포인자.기중IL-21재자신면역병、면역결함병급종류중도기중요적작용.T+세포적발현봉부료인문대CD4+T세포아군적인식,탁전료대각충면역성질병적발병궤제적인식.
Antibody production with the help of T cells is a fundamental aspect of humoral immune responses induced by thymus dependent antigens. Th2 cells were long considered to be the cells that provided help to B cells. It is now believed that the helper role is played by a newly found subset of CD4+ T cells TFH. The devel-opment of TFH is IL-21 dependent. TFH with clear phenotype of CD4+CXCR5+ is predominantly located in B cell follicles, and characterized by the secretion of IL-21 and other cytokines. IL-21 is involved in autoimmuni-ty, inflammatory diseases and tumor. A better understanding of the TFH subset of CD4+T cells may provide new insight in the recognition of the mechanisms of immune diseases.