CAJ | 학술논문

趋化因子是机体内一群能使白细胞发生趋化运动的小分子细胞因子,CC趋化因子为其中的一类,CCL20是活性相关趋化性细胞因子,属于CC家族中的一员,与炎症及免疫反应密切相关.吸烟可以引起气道的慢性炎症,发生不完全可逆的呼气性气流受限和肺功能下降.然而吸烟停止后,慢性阻塞性肺疾病(COPD)患者气道的慢性炎症仍持续发展,提示免疫因素可能参与了COPD的发病过程.本文主要探讨CCL20与COPD的关系.
추화인자시궤체내일군능사백세포발생추화운동적소분자세포인자,CC추화인자위기중적일류,CCL20시활성상관추화성세포인자,속우CC가족중적일원,여염증급면역반응밀절상관.흡연가이인기기도적만성염증,발생불완전가역적호기성기류수한화폐공능하강.연이흡연정지후,만성조새성폐질병(COPD)환자기도적만성염증잉지속발전,제시면역인소가능삼여료COPD적발병과정.본문주요탐토CCL20여COPD적관계.
Chemotactic factors,a group of small molecule cytokines in body,can make leucocytes occur chemotactic movement.Belonging to CC family,which is one kind of chemotactic factors,CCL20s are activity-related chemokines. It has been generally considered CCL20 plays a significant role in inflammation and immunoreaction.Smoking can cause chronic airway inflammation,irreversible expriatory airflow limitation and lung function decline.Even after quit smoking,inflammation in chronic obstructive pulmonary disease (COPD) patients' airway continue to develop,which suggests immune factors may be involved in the pathogenesis of COPD. This paper investigates the relationship between CCL20 and COPD.