中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
7期
1-3
,共3页
章惺惺%吴文俊%陈咨苗%蔡雪黎%汪大望
章惺惺%吳文俊%陳咨苗%蔡雪黎%汪大望
장성성%오문준%진자묘%채설려%왕대망
基质金属蛋白酶9%C反应蛋白质%糖尿病,2型%冠状动脉疾病
基質金屬蛋白酶9%C反應蛋白質%糖尿病,2型%冠狀動脈疾病
기질금속단백매9%C반응단백질%당뇨병,2형%관상동맥질병
Matrix metalloproteinase 9%C-reactive protein%Diabetes mellitus,type 2%Coronary disease
目的 探讨血清基质金属蛋白酶-9(MMP-9)及高敏C反应蛋白(hs-CRP)水平与2型糖尿病(T2DM)合并冠心病(CHD)的关系,并评价其临床意义.方法 选取T2DM合并CHD患者31例(T2DM合并CHD组),单纯CHD患者50例(单纯CHD组),门诊健康体检者30例(对照组).用酶联免疫吸附法检测血清MMP-9的水平,用免疫散射比浊法检测血清hs-CRP的水平.结果 T2DM合并CHD组血清MMP-9中位水平为409.62 μg/L,显著高于单纯CHD组的263.40 μg/L及对照组的(196.15±44.89)μg/L,差异有统计学意义(P<0.05).T2DM合并CHD组血清hs-CRP中位水平为17.20 mg/L,明显高于单纯CHD组的4.57 mg/L及对照组的(1.52±0.78)mg/L,差异有统计学意义(P<0.01).T2DM合并CHD组患者血清MMP-9与hs-CRP呈正相关(r=0.482,P<0.01).结论 血清MMP-9、hs-CRP与糖尿病冠状动脉粥样硬化的发生、发展密切相关.
目的 探討血清基質金屬蛋白酶-9(MMP-9)及高敏C反應蛋白(hs-CRP)水平與2型糖尿病(T2DM)閤併冠心病(CHD)的關繫,併評價其臨床意義.方法 選取T2DM閤併CHD患者31例(T2DM閤併CHD組),單純CHD患者50例(單純CHD組),門診健康體檢者30例(對照組).用酶聯免疫吸附法檢測血清MMP-9的水平,用免疫散射比濁法檢測血清hs-CRP的水平.結果 T2DM閤併CHD組血清MMP-9中位水平為409.62 μg/L,顯著高于單純CHD組的263.40 μg/L及對照組的(196.15±44.89)μg/L,差異有統計學意義(P<0.05).T2DM閤併CHD組血清hs-CRP中位水平為17.20 mg/L,明顯高于單純CHD組的4.57 mg/L及對照組的(1.52±0.78)mg/L,差異有統計學意義(P<0.01).T2DM閤併CHD組患者血清MMP-9與hs-CRP呈正相關(r=0.482,P<0.01).結論 血清MMP-9、hs-CRP與糖尿病冠狀動脈粥樣硬化的髮生、髮展密切相關.
목적 탐토혈청기질금속단백매-9(MMP-9)급고민C반응단백(hs-CRP)수평여2형당뇨병(T2DM)합병관심병(CHD)적관계,병평개기림상의의.방법 선취T2DM합병CHD환자31례(T2DM합병CHD조),단순CHD환자50례(단순CHD조),문진건강체검자30례(대조조).용매련면역흡부법검측혈청MMP-9적수평,용면역산사비탁법검측혈청hs-CRP적수평.결과 T2DM합병CHD조혈청MMP-9중위수평위409.62 μg/L,현저고우단순CHD조적263.40 μg/L급대조조적(196.15±44.89)μg/L,차이유통계학의의(P<0.05).T2DM합병CHD조혈청hs-CRP중위수평위17.20 mg/L,명현고우단순CHD조적4.57 mg/L급대조조적(1.52±0.78)mg/L,차이유통계학의의(P<0.01).T2DM합병CHD조환자혈청MMP-9여hs-CRP정정상관(r=0.482,P<0.01).결론 혈청MMP-9、hs-CRP여당뇨병관상동맥죽양경화적발생、발전밀절상관.
Objective To investigate the effect of matrix metalloproteinas-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) combined with coronary heart disease(CHD). Methods Thirty-one patients with T2DM combined with CHD(T2DM combined with CHD group) ,50 patients with CHD (CHD group) and 30 healthy volunteers (control group) were studied. Serum MMP-9 was measured by ELISA, and serum hs-CRP was measured by scattering immunoturbidimetric assay. Results The level of MMP-9 in T2DM combined with CHD group (409.62 μg/L) was significantly higher than that in CHD group (263.40 μg/L) and control group [(196.15 ±44.89) μg/L] (P < 0.05).The level of hs-CRP in T2DM combined with CHD group (17.20 mg/L) was significantly higher than that in CHD group (4.57 mg/L) and control group [(1.52±0.78) mg/L] (P <0.01). MMP-9 wa significantly related with hs-CRP in T2DM combined with C HD group (r = 0.482,P < 0.01). Conclusion The serum M MP-9 and hs-CRP levels are closely associated with the occurrence and development of diabetes related coronary atherosclerosis.
