CAJ | 학술논문

目的探讨束颤电位在肌萎缩侧索硬化诊断中的作用.方法对2009年8月至2010年8月就诊于北京大学第三医院神经科的60例肌萎缩侧索硬化患者进行常规肌电图检测,包括针极肌电图、神经传导速度等,其中肌电图静息状态下束颤电位的检测条件为:患者保持所检测肌肉放松,检测者取同心圆针电极进行检测,记录条件:带通20 Hz至10 kHz,扫描速度为5 ms/D,灵敏度在0.05～0.5 mV/D的范围内调节,每块肌肉观察1～5 min,记录束颤电位的波幅、时限和相位数.结果胸锁乳突肌中,束颤电位的出现率高于纤颤电位和正锐波(36.7%比13.3%,x2=8.71,P＜0.05),病程18个月以上患者束颤电位波幅和时限高于发病8个月以下患者[(1.8±0.9)mV,(1.0±0.6)mV;(15.2±4.1)ms,(11.2±3.0)ms;q=3.43,3.51,P＜0.05),如果把束颤电位列入急性失神经表现,肌萎缩侧索硬化确诊级别患者可以增加(80%比60%;x2=5.71,P=0.02).结论束颤电位对于肌萎缩侧索硬化的早期诊断可能有重要意义,在疾病的不同时期,束颤电位形态不同.
목적 탐토속전전위재기위축측색경화진단중적작용.방법 대2009년8월지2010년8월취진우북경대학제삼의원신경과적60례기위축측색경화환자진행상규기전도검측,포괄침겁기전도、신경전도속도등,기중기전도정식상태하속전전위적검측조건위:환자보지소검측기육방송,검측자취동심원침전겁진행검측,기록조건:대통20 Hz지10 kHz,소묘속도위5 ms/D,령민도재0.05～0.5 mV/D적범위내조절,매괴기육관찰1～5 min,기록속전전위적파폭、시한화상위수.결과 흉쇄유돌기중,속전전위적출현솔고우섬전전위화정예파(36.7%비13.3%,x2=8.71,P＜0.05),병정18개월이상환자속전전위파폭화시한고우발병8개월이하환자[(1.8±0.9)mV,(1.0±0.6)mV;(15.2±4.1)ms,(11.2±3.0)ms;q=3.43,3.51,P＜0.05),여과파속전전위렬입급성실신경표현,기위축측색경화학진급별환자가이증가(80%비60%;x2=5.71,P=0.02).결론 속전전위대우기위축측색경화적조기진단가능유중요의의,재질병적불동시기,속전전위형태불동.
Objective To explore the role of fasciculation potentials in the diagnosis of amyotrophic lateral sclerosis (ALS). Methods A total of 60 ALS patients were recruited from August 2009 to August 2010 at our hospital. Standard examinations of electromyography and nerve conduction were performed. And fasciculation potentials were measured in the resting muscles with a band pass of 20 Hz - 10 kHz, a sensitivity of 0. 05 - 0. 5 mV/D and a sweep speed of 5 ms/D. Each muscle was observed for 1 - 5 minutes. The amplitude, duration and phase of fasciculation potentials were recorded. Results The occurrence rate of fasciculation potential in sternocleidomastoid was more than that of fibrillation and positive sharp wave in ALS patients ( 36. 7% vs 13.3%, x2 = 8.71, P ＜ 0. 05 ). The amplitude and duration of fasciculation potentials in ALS patients with a duration of over 18 months were higher than that of those with a duration of under 8 months [ ( 1.8 ± 0. 9) mV, ( 1.0 ± 0. 6) mV; ( 15.2 ± 4. 1 ) ms, ( 11.2 ± 3. 0) ms;q =3.43, 3.51, P ＜0. 05 )]. The patients with definite ALS might increase if fasciculation potentials were considered as spontaneous potential ( 80% vs 60%; x2 = 5.71, P = 0. 02). Conclusion With different morphologies at different disease stages, fasciculation potentials may be useful in the earlier diagnosis of amyotrophic lateral sclerosis.