中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
3期
4-5
,共2页
前白蛋白%丁酰胆碱酯酶%腺苷脱氨酶%肝硬化%Child-Pugh分级
前白蛋白%丁酰膽堿酯酶%腺苷脫氨酶%肝硬化%Child-Pugh分級
전백단백%정선담감지매%선감탈안매%간경화%Child-Pugh분급
Prealbumin%Butyrylcholinesterase%Adenosine deaminase%Cirrhosis%Child-Pugh classification
目的 研究血清前白蛋白(PA)、丁酰胆碱酯酶(BuChE)和腺苷脱氨酶(ADA)的检测在肝硬化Child-Pugh分级中的应用价值.方法 测定87例肝硬化患者和50例健康人血清PA、BuChE和ADA及肝功能指标(包括白蛋白、胆红素、丙氨酸氨基转移酶),并按Child分级标准进行分组比较.结果 肝硬化组PA含量和BuChE活性较正常对照组显著降低(P<0.01),ADA活性明显升高(P<0.01);按Child-Pugh分级,PA含量和BuChE活性随肝硬化的程度加重而降低,ADA活性则随肝硬化的程度加重而升高,各级之间差异均有统计学意义(P<0.01).结论 血清PA含量、BuChE和ADA活性的检测对判断肝硬化程度具有重要的指导意义,可作为肝硬化患者病情诊断和预后判断的指标.
目的 研究血清前白蛋白(PA)、丁酰膽堿酯酶(BuChE)和腺苷脫氨酶(ADA)的檢測在肝硬化Child-Pugh分級中的應用價值.方法 測定87例肝硬化患者和50例健康人血清PA、BuChE和ADA及肝功能指標(包括白蛋白、膽紅素、丙氨痠氨基轉移酶),併按Child分級標準進行分組比較.結果 肝硬化組PA含量和BuChE活性較正常對照組顯著降低(P<0.01),ADA活性明顯升高(P<0.01);按Child-Pugh分級,PA含量和BuChE活性隨肝硬化的程度加重而降低,ADA活性則隨肝硬化的程度加重而升高,各級之間差異均有統計學意義(P<0.01).結論 血清PA含量、BuChE和ADA活性的檢測對判斷肝硬化程度具有重要的指導意義,可作為肝硬化患者病情診斷和預後判斷的指標.
목적 연구혈청전백단백(PA)、정선담감지매(BuChE)화선감탈안매(ADA)적검측재간경화Child-Pugh분급중적응용개치.방법 측정87례간경화환자화50례건강인혈청PA、BuChE화ADA급간공능지표(포괄백단백、담홍소、병안산안기전이매),병안Child분급표준진행분조비교.결과 간경화조PA함량화BuChE활성교정상대조조현저강저(P<0.01),ADA활성명현승고(P<0.01);안Child-Pugh분급,PA함량화BuChE활성수간경화적정도가중이강저,ADA활성칙수간경화적정도가중이승고,각급지간차이균유통계학의의(P<0.01).결론 혈청PA함량、BuChE화ADA활성적검측대판단간경화정도구유중요적지도의의,가작위간경화환자병정진단화예후판단적지표.
Objective To study the clinical value of serum prealbumin(PA) and butyrylcholinesterase(BuChE) and adenosine deaminase(ADA) in Child-Pugh classification of cirrhosis. Methods Eighty-seven serum samples of patients with cirrhosis and 50 serum samples of the healthy were detected for PA,BuChE and ADA,while hepatic functional indexes:serum albumin,total bilirubin and alanine aminotransferase were also detected,and the patients were classified according to the Child-Pugh score. Results Compared with the results of healthy group,the level of PA and the activity of BuChE sharply declined in cirrhotic patients,while the serum ADA level increased significantly.According to the Child-Pugh classification,PA,BuChE and ADA in different groups varied obviously. Conclusions The level of PA and the activity of BuChE,ADA in serum have an important significance in diagnosing the extent of liver damage,which can be regarded as effective indexes on diagnosis of patients'state and prognostic evaluation of cirrhosis.
