中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
24期
29-30
,共2页
地特胰岛素%二甲双胍%2型糖尿病%C-反应蛋白%血脂
地特胰島素%二甲雙胍%2型糖尿病%C-反應蛋白%血脂
지특이도소%이갑쌍고%2형당뇨병%C-반응단백%혈지
Insulin detemir%Metformin%Type 2 diabetes%C - reactive protein%Blood fat
目的 分析地特胰岛素联合二甲双胍对初诊2型糖尿病患者血浆C -反应蛋白(CRP)和血脂的影响.方法 选取新诊断2型糖尿病患者100例进行地特胰岛素起始剂量10 U与二甲双胍0.5g,3次/d联合治疗,疗程为12周,另入选100例同期进行健康体检的正常人群为正常对照组,观察两组研究对象基线血糖指标,血脂以及炎症因子CRP差异,并比较2型糖尿病组治疗前后血糖指标、血脂和CRP的变化.结果 治疗前2型糖尿病组的血糖指标、血脂及CRP明显高于对照组,其他基础临床资料比较差异无统计学意义(P＞0.05).治疗12周后2型糖尿病组的血糖指标、血脂和血浆CRP浓度,较治疗前明显下降(P＜0.01).结论 地特胰岛素与二甲双胍联合治疗可以改善初诊2型糖尿病患者的糖代谢,降低患者血浆CRP的浓度,降低胆固醇、甘油三酯和低密度脂蛋白.
目的 分析地特胰島素聯閤二甲雙胍對初診2型糖尿病患者血漿C -反應蛋白(CRP)和血脂的影響.方法 選取新診斷2型糖尿病患者100例進行地特胰島素起始劑量10 U與二甲雙胍0.5g,3次/d聯閤治療,療程為12週,另入選100例同期進行健康體檢的正常人群為正常對照組,觀察兩組研究對象基線血糖指標,血脂以及炎癥因子CRP差異,併比較2型糖尿病組治療前後血糖指標、血脂和CRP的變化.結果 治療前2型糖尿病組的血糖指標、血脂及CRP明顯高于對照組,其他基礎臨床資料比較差異無統計學意義(P＞0.05).治療12週後2型糖尿病組的血糖指標、血脂和血漿CRP濃度,較治療前明顯下降(P＜0.01).結論 地特胰島素與二甲雙胍聯閤治療可以改善初診2型糖尿病患者的糖代謝,降低患者血漿CRP的濃度,降低膽固醇、甘油三酯和低密度脂蛋白.
목적 분석지특이도소연합이갑쌍고대초진2형당뇨병환자혈장C -반응단백(CRP)화혈지적영향.방법 선취신진단2형당뇨병환자100례진행지특이도소기시제량10 U여이갑쌍고0.5g,3차/d연합치료,료정위12주,령입선100례동기진행건강체검적정상인군위정상대조조,관찰량조연구대상기선혈당지표,혈지이급염증인자CRP차이,병비교2형당뇨병조치료전후혈당지표、혈지화CRP적변화.결과 치료전2형당뇨병조적혈당지표、혈지급CRP명현고우대조조,기타기출림상자료비교차이무통계학의의(P＞0.05).치료12주후2형당뇨병조적혈당지표、혈지화혈장CRP농도,교치료전명현하강(P＜0.01).결론 지특이도소여이갑쌍고연합치료가이개선초진2형당뇨병환자적당대사,강저환자혈장CRP적농도,강저담고순、감유삼지화저밀도지단백.
Objective To observe the effects of insulin detemir plus metformin on C -reactive protein and blood fat in the treatment of patients with newly diagnosed type 2 diabetes.Methods One hundred patients with newly diagnosed type 2 diabetes were given insulin detemir (beginning dose 10 U/d and metmormin 0.5 g,tid for 12 weeks;while 100 cases selected for the same period from the normal healthy population were taken as control group.Both groups' baseline blood glucose,blood fat and C -reactive protein were observed.Results Before treatment,blood glucose targets,blood fat and C - reactive protein in type 2 diabetes group were obviously higher than those in control group,but there were no difference in other clinical datas.After 12 weeks' treatment,in type 2 diabetes group,there was a significant decreased in blood glucose targets,blood fat and C - reactive protein (P ＜ 0.01 ).Conclusions Insulin detemir and metformin combined therapy can improve glucosed metabolism in patients with newly diagnosed type 2 diabetes,and decrease the plasma concentration of CRP,TC,TG and LDL- C.
