CAJ | 학술논문

骨生长因子是由骨细胞产生,并贮存在基质中,具有调节骨生长作用的一类生长因子.骨发育与基因调控有关,目前发现了很多种该类因子,通过自分泌和旁分泌方式在骨的形成和吸收过程中起作用.核心结合因子α_1和雌激素受体α的基因是近年来研究与骨生长发育有关的热点因子.基因的多态性属于基因水平上的变异,一般发生在基因序列中不编码蛋白的区域和没有重要调节功能的区域.文章就骨生长因子中的核心结合因子α_1和雌激素受体α的基因多态性与骨发育相关性的研究现状进行探讨.
골생장인자시유골세포산생,병저존재기질중,구유조절골생장작용적일류생장인자.골발육여기인조공유관,목전발현료흔다충해류인자,통과자분비화방분비방식재골적형성화흡수과정중기작용.핵심결합인자α_1화자격소수체α적기인시근년래연구여골생장발육유관적열점인자.기인적다태성속우기인수평상적변이,일반발생재기인서렬중불편마단백적구역화몰유중요조절공능적구역.문장취골생장인자중적핵심결합인자α_1화자격소수체α적기인다태성여골발육상관성적연구현상진행탐토.
Produced by bone cells and stored in the matrix.bone ceil growth factor can contribute to the regulation of bone growth.Gene regulation has its role in bone development.Many factors of this kind have been founded recently.They play their role during the bone formation and absorption processes in the way of autocrine and paracrine.The genes of core binding factor α_1(Cbfα_1)and estrogen receptor α(Erα)have been the recent years'hot factors that are related to the bone development,Gene polymorphism refers to variation on gene level which often occurs in the non-coding domain or the domain bearing no important regulatory function in gene order.This article reviewed the research status of the relation between Cbfα_1 and Erα gene polymorphism with bone development.