CAJ | 학술논문

目的:初步探讨双背侧前额叶低频重复经颅磁刺激(rTMS)治疗精神分裂症顽固性幻听的疗效和安全性,并观察其副反应.方法:25例伴顽固性幻听的精神分裂症患者随机分为rTMS治疗组(N=12)和对照组(N=13),分别给予10次1Hz rTMS真刺激和伪刺激治疗,治疗期间维持原有抗精神病药种类及剂量不变.采用阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评定临床症状,采用治疗中需处理的不良反应症状量表(Treatment Emergent Symptom Scale,TESS)等检查评估副反应.结果:25例患者均完成治疗,治疗组有效率高于对照组(75% vs.31%,P<0.05).未观察到明显副反应.结论:1 Hz双背侧前额叶低频重复经颅磁刺激治疗精神分裂症顽固性幻听可能有效,且安全性好,值得进一步研究.
목적:초보탐토쌍배측전액협저빈중복경로자자격(rTMS)치료정신분렬증완고성환은적료효화안전성,병관찰기부반응.방법:25례반완고성환은적정신분렬증환자수궤분위rTMS치료조(N=12)화대조조(N=13),분별급여10차1Hz rTMS진자격화위자격치료,치료기간유지원유항정신병약충류급제량불변.채용양성화음성증상량표(Positive and Negative Syndrome Scale,PANSS)평정림상증상,채용치료중수처리적불량반응증상량표(Treatment Emergent Symptom Scale,TESS)등검사평고부반응.결과:25례환자균완성치료,치료조유효솔고우대조조(75% vs.31%,P<0.05).미관찰도명현부반응.결론:1 Hz쌍배측전액협저빈중복경로자자격치료정신분렬증완고성환은가능유효,차안전성호,치득진일보연구.
Objective: To examine the therapeutic effects of dual dorsolateral prefrontal repetitive transcranial magnetic stimulation (rTMS) on auditory hallucinations experienced by schizophrenic patients. Methods: A double-blind randomized controlled study was conducted. Totally 25 schizophrenic patients met DSM-Ⅳ criteria for schizophrenia and had anditory hallucination with stable antipsychotic drugs treatment were recruited. Subjects were grouped into active treatment subgroup and sham subgroup randomly. Measurements including the Positive and Negative Symptom Scale (PANSS) for clinical symptom and the Treatment Emergent Symptom Scale (TESS) for side-effects were evaluated Results: Totally 25 subjects completed the trial. The treatment efficiency of active treatment group was higher than that of sham group (75% vs. 31%) .No overt side effects of rTMS were observed. Conclusion: It is effective for rTMS to treat schizophrenia with auditory hallucination at 1Hz. rTMS may be a new selection of schizophrenia treatment.